Distinct Single Cell Gene Expression in Peripheral Blood Monocytes Correlates With Tumor Necrosis Factor Inhibitor Treatment Response Groups Defined by Type I Interferon in Rheumatoid Arthritis.
interferon-alpha
interferon-beta
janus kinase 1
monocyte
rheumatoid arthritis
single cell
tumor necrosis factor-alpha
type I interferon
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
10
01
2020
accepted:
29
05
2020
entrez:
9
8
2020
pubmed:
9
8
2020
medline:
7
4
2021
Statut:
epublish
Résumé
Previously, we demonstrated in test and validation cohorts that type I IFN (T1IFN) activity can predict non-response to tumor necrosis factor inhibitors (TNFi) in rheumatoid arthritis (RA). In this study, we examine the biology of non-classical and classical monocytes from RA patients defined by their pre-biologic treatment T1IFN activity. We compared single cell gene expression in purified classical (CL,
Identifiants
pubmed: 32765497
doi: 10.3389/fimmu.2020.01384
pmc: PMC7378891
doi:
Substances chimiques
Antirheumatic Agents
0
Interferon Type I
0
Tumor Necrosis Factor Inhibitors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1384Informations de copyright
Copyright © 2020 Wampler Muskardin, Fan, Jin, Jensen, Dorschner, Ghodke-Puranik, Dicke, Vsetecka, Wright, Mason, Persellin, Michet, Davis, Matteson and Niewold.
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