In and Out of the Bursa-The Role of CXCR4 in Chicken B Cell Development.
Animals
Animals, Genetically Modified
Avian Proteins
/ genetics
B-Lymphocytes
/ physiology
Bursa of Fabricius
/ physiology
Cell Differentiation
Cell Movement
Chemokine CXCL12
/ genetics
Chick Embryo
Chickens
Gene Expression Regulation
Humans
Lymphocyte Activation
Receptors, CXCR4
/ metabolism
Signal Transduction
B cell development
Bursa fabricii
CXCL12
CXCR4
cell migration
chicken
follicle cortex
follicle medulla
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
23
01
2020
accepted:
05
06
2020
entrez:
9
8
2020
pubmed:
9
8
2020
medline:
17
4
2021
Statut:
epublish
Résumé
In contrast to mammals, early B cell differentiation and diversification of the antibody repertoire in chickens do not take place in the bone marrow but in a specialized gut associated lymphoid tissue (GALT), the bursa of Fabricius. During embryonic development, B cell precursors migrate to the bursa anlage, where they proliferate and diversify their B cell receptor repertoire. Around hatch these diversified B cells start to emigrate from the bursa of Fabricius and populate peripheral lymphoid organs, but very little is known how the migratory processes are regulated. As CXCL12 (syn. SDF-1) and CXCR4 were shown to be essential for the control of B cell migration during the development of lymphoid tissues in mammals, we analyzed expression and function of this chemokine/chemokine-receptor pair in the chicken bursa. We found a strong variation of mRNA abundance of CXCL12 and CXCR4 in different stages of bursa development, with high abundance of CXCL12 mRNA in the bursa anlage at embryonic day 10 (ED10).
Identifiants
pubmed: 32765509
doi: 10.3389/fimmu.2020.01468
pmc: PMC7381227
doi:
Substances chimiques
Avian Proteins
0
Chemokine CXCL12
0
Receptors, CXCR4
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1468Informations de copyright
Copyright © 2020 Nagy, Busalt, Halasy, Kohn, Schmieder, Fejszak, Kaspers and Härtle.
Références
Eur J Immunol. 1993 Jan;23(1):96-102
pubmed: 8419193
Genes Dev. 1989 Jun;3(6):838-47
pubmed: 2501152
Anat Embryol (Berl). 2004 May;208(2):97-107
pubmed: 15052478
Mol Immunol. 2013 Jun;54(2):140-7
pubmed: 23270685
Development. 2014 Aug;141(16):3255-65
pubmed: 25063453
Dev Comp Immunol. 2005;29(2):143-52
pubmed: 15450754
Dev Dyn. 2006 Nov;235(11):3007-15
pubmed: 16958136
Annu Rev Immunol. 1991;9:219-41
pubmed: 1910677
Vet Immunol Immunopathol. 2002 Sep 10;87(3-4):337-40
pubmed: 12072255
Adv Exp Med Biol. 1994;355:249-53
pubmed: 7709830
Eur J Immunol. 1983 Jul;13(7):590-5
pubmed: 6135615
Cell Tissue Res. 2017 May;368(2):353-370
pubmed: 28353134
Science. 2016 May 13;352(6287):aaf4822
pubmed: 27174992
Anat Rec. 1995 Nov;243(3):384-9
pubmed: 8579258
J Exp Med. 2014 Dec 15;211(13):2567-81
pubmed: 25403444
Dev Dyn. 2010 Jun;239(6):1622-31
pubmed: 20503359
Blood. 1999 Nov 1;94(9):2990-8
pubmed: 10556181
Eur J Immunol. 1995 Sep;25(9):2544-50
pubmed: 7589124
Int Arch Allergy Appl Immunol. 1969;35(3):242-52
pubmed: 4179663
EMBO Rep. 2004 Jul;5(7):728-33
pubmed: 15192698
Cell. 1991 Mar 8;64(5):995-1005
pubmed: 1900459
Dev Comp Immunol. 2016 May;58:47-59
pubmed: 26751596
Front Immunol. 2020 Jan 10;10:3057
pubmed: 31998323
J Immunol. 2014 Dec 15;193(12):5951-9
pubmed: 25385821
Proc Natl Acad Sci U S A. 1975 Jul;72(7):2701-5
pubmed: 1101262
Immunity. 1994 Nov;1(8):647-59
pubmed: 7600292
Nat Immunol. 2004 Sep;5(9):943-52
pubmed: 15300245
Immunity. 1999 Apr;10(4):463-71
pubmed: 10229189
Comp Immunol Microbiol Infect Dis. 1998 Jul;21(3):179-89
pubmed: 9681241
Vet Res. 2006 May-Jun;37(3):401-15
pubmed: 16611555
Circ Res. 2013 Aug 16;113(5):505-16
pubmed: 23838132
Anat Rec. 2001 Mar 1;262(3):279-92
pubmed: 11241196
Proc Natl Acad Sci U S A. 1990 Dec;87(23):9416-20
pubmed: 2123557
Methods Cell Biol. 2008;87:169-85
pubmed: 18485297
Dev Biol. 1976 Oct 15;53(2):250-64
pubmed: 992209
Proc Natl Acad Sci U S A. 1994 Mar 15;91(6):2305-9
pubmed: 8134392
J Leukoc Biol. 2001 Feb;69(2):297-305
pubmed: 11272281
Int J Dev Biol. 2008;52(1):87-92
pubmed: 18033676
Eur J Immunol. 1989 May;19(5):955-8
pubmed: 2500350
Poult Sci. 1993 Nov;72(11):2084-94
pubmed: 7505435
Blood. 2012 Jan 19;119(3):707-16
pubmed: 22049516
Nature. 2015 Sep 24;525(7570):528-32
pubmed: 26374999
Immunology. 1985 Jul;55(3):405-10
pubmed: 3926634
Immunol Today. 1985 Jul;6(7):223-7
pubmed: 25290185
J Interferon Cytokine Res. 2005 Aug;25(8):467-84
pubmed: 16108730
Eur J Immunol. 1994 Feb;24(2):458-63
pubmed: 8299695
Dev Biol. 2004 Aug 15;272(2):351-61
pubmed: 15282153
J Exp Med. 2001 Jul 2;194(1):45-56
pubmed: 11435471
J Anat. 2018 Oct;233(4):401-410
pubmed: 30022489
Development. 1995 Jun;121(6):1657-67
pubmed: 7600983
J Clin Invest. 2015 Jun;125(6):2203-10
pubmed: 25938781
J Exp Med. 1995 Jan 1;181(1):105-13
pubmed: 7806997
Proteomics. 2013 Jan;13(1):119-33
pubmed: 23135993
J Immunol. 1995 Dec 15;155(12):5550-6
pubmed: 7499837
Dev Comp Immunol. 1984 Winter;8(1):219-24
pubmed: 6724090