Polymorphisms in
Matrix metalloproteinases
Metallothioneins
Polymorphisms
Prostate cancer
Journal
Hereditary cancer in clinical practice
ISSN: 1731-2302
Titre abrégé: Hered Cancer Clin Pract
Pays: Poland
ID NLM: 101231179
Informations de publication
Date de publication:
2020
2020
Historique:
received:
14
04
2020
accepted:
24
07
2020
entrez:
9
8
2020
pubmed:
9
8
2020
medline:
9
8
2020
Statut:
epublish
Résumé
Matrix metalloproteinases (MMPs) and metallothioneins (MTs) are Zinc-related proteins which are involved in processes crucial for carcinogenesis such as angiogenesis, proliferation and apoptosis. Several single nucleotide polymorphisms (SNPs) in MMPs and MTs that affect genes expression have been associated with cancer risk, including breast, lung and colon. The study group consisted of 648 unselected patients (299 with breast cancer, 199 with lung cancer, 150 with colon cancer) and 648 unaffected individuals. Five SNPs, rs1799750 in None of the 5 tested polymorphisms showed a correlation with cancer risk in studied groups, although for Analyses of polymorphisms, rs1799750 in
Sections du résumé
BACKGROUND
BACKGROUND
Matrix metalloproteinases (MMPs) and metallothioneins (MTs) are Zinc-related proteins which are involved in processes crucial for carcinogenesis such as angiogenesis, proliferation and apoptosis. Several single nucleotide polymorphisms (SNPs) in MMPs and MTs that affect genes expression have been associated with cancer risk, including breast, lung and colon.
METHODS
METHODS
The study group consisted of 648 unselected patients (299 with breast cancer, 199 with lung cancer, 150 with colon cancer) and 648 unaffected individuals. Five SNPs, rs1799750 in
RESULTS
RESULTS
None of the 5 tested polymorphisms showed a correlation with cancer risk in studied groups, although for
CONCLUSIONS
CONCLUSIONS
Analyses of polymorphisms, rs1799750 in
Identifiants
pubmed: 32765800
doi: 10.1186/s13053-020-00147-w
pii: 147
pmc: PMC7395404
doi:
Types de publication
Journal Article
Langues
eng
Pagination
16Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestsJL is CEO of Read-Gene S.A. The authors WM, MM are employees of Read-Gene S.A. KB, PB, SG, KJB, GS, KD, TG, ML, KP, AŁ, CC, TH, JG, TD, AJ declare that they have no competing interests.
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