Role of tumor suppressor molecules in genomic perturbations and damaged DNA repair involved in the pathogenesis of cancer and neurodegeneration (Review).
BRCA1
DNA repair
PTEN
TP53
aging
carcinogenesis
cell signaling
genomic stability
neurodegeneration
reactive oxygen species
Journal
Biomedical reports
ISSN: 2049-9434
Titre abrégé: Biomed Rep
Pays: England
ID NLM: 101613227
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
14
12
2018
accepted:
11
05
2020
entrez:
9
8
2020
pubmed:
9
8
2020
medline:
9
8
2020
Statut:
ppublish
Résumé
Genomic perturbations due to inaccurate DNA replication, including inappropriate chromosomal segregation often underlie the development of cancer and neurodegenerative diseases. The incidence of these two diseases increases with age and exhibits an inverse association. Therefore, elderly subjects with cancer exhibit a reduced risk of a neurodegenerative disease, and vice versa. Both of these diseases are associated with aging and share several risk factors. Cells have multiple mechanisms to repair DNA damage and inaccurate replication. Previous studies have demonstrated that tumor suppressor proteins serve a critical role in the DNA damage response, which may result in genomic instability and thus induction of cellular apoptosis. Tumor suppressor genes, such as phosphatase and tensin homologue deleted on chromosome 10
Identifiants
pubmed: 32765849
doi: 10.3892/br.2020.1317
pii: BR-0-0-01317
pmc: PMC7391300
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
10Informations de copyright
Copyright: © Matsuda et al.
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