Unravelling the Role of HSP70 as the Unexplored Molecular Target in Age-Related Macular Degeneration.
age-related macular degeneration
apoptosis
heat shock protein 70
hne
inflammation
oxidative stress
retinal pigment epithelial cell
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
02 Jul 2020
02 Jul 2020
Historique:
entrez:
9
8
2020
pubmed:
9
8
2020
medline:
9
8
2020
Statut:
epublish
Résumé
The motive behind writing this paper was to highlight the relationship between heat shock protein 70 (HSP70) and age-related macular degeneration (AMD) to explore the potential role of HSP70 as a molecular target in AMD therapy. We performed a comprehensive literature search in various databases and finally found 43 relevant studies related to our objective. In our research, we found that in AMD, oxidative stress causes increased inflammation and excessive apoptosis due to the accumulation of aberrant proteins in retinal pigment epithelium (RPE) cells. The long-lasting overstimulation of the defence system leads to RPE degeneration and results in visual impairment or vision loss. However, after thorough research, it was found that HSP70's role as an immunomodulator, the guardian of the proteolytic pathway and regulator of apoptosis makes it a potential therapeutic target in AMD.
Identifiants
pubmed: 32766003
doi: 10.7759/cureus.8960
pmc: PMC7398729
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e8960Informations de copyright
Copyright © 2020, Kumar et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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