Single-Sample Node Entropy for Molecular Transition in Pre-deterioration Stage of Cancer.
cancer molecular network
critical transition stage
drug targets
dynamic network biomarker
single-sample node entropy
Journal
Frontiers in bioengineering and biotechnology
ISSN: 2296-4185
Titre abrégé: Front Bioeng Biotechnol
Pays: Switzerland
ID NLM: 101632513
Informations de publication
Date de publication:
2020
2020
Historique:
received:
07
05
2020
accepted:
23
06
2020
entrez:
9
8
2020
pubmed:
9
8
2020
medline:
9
8
2020
Statut:
epublish
Résumé
A complex disease, especially cancer, always has pre-deterioration stage during its progression, which is difficult to identify but crucial to drug research and clinical intervention. However, using a few samples to find mechanisms that propel cancer crossing the pre-deterioration stage is still a complex problem. In this study, we successfully developed a novel single-sample model based on node entropy with
Identifiants
pubmed: 32766227
doi: 10.3389/fbioe.2020.00809
pmc: PMC7381145
doi:
Types de publication
Journal Article
Langues
eng
Pagination
809Informations de copyright
Copyright © 2020 Han, Zhong, Hu, Liu, Liu and Ling.
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