The role of protein arginine methyltransferases in kidney diseases.
Methylation
acute kidney injury
diabetic nephropathy
posttranslational modification
protein arginine methyltransferases
renal fibrosis
Journal
Clinical science (London, England : 1979)
ISSN: 1470-8736
Titre abrégé: Clin Sci (Lond)
Pays: England
ID NLM: 7905731
Informations de publication
Date de publication:
14 08 2020
14 08 2020
Historique:
received:
21
05
2020
revised:
22
07
2020
accepted:
27
07
2020
entrez:
9
8
2020
pubmed:
9
8
2020
medline:
30
12
2020
Statut:
ppublish
Résumé
The methylation of arginine residues by protein arginine methyltransferases (PRMTs) is a crucial post-translational modification for many biological processes, including DNA repair, RNA processing, and transduction of intra- and extracellular signaling. Previous studies have reported that PRMTs are extensively involved in various pathologic states, including cancer, inflammation, and oxidative stress reaction. However, the role of PRMTs has not been well described in kidney diseases. Recent studies have shown that aberrant function of PRMTs and its metabolic products-symmetric dimethylarginine (SDMA) and asymmetric dimethylarginine (ADMA)-are involved in several renal pathological processes, including renal fibrosis, acute kidney injury (AKI), diabetic nephropathy (DN), hypertension, graft rejection and renal tumors. We aim in this review to elucidate the possible roles of PRMTs in normal renal function and various kidney diseases.
Identifiants
pubmed: 32766778
pii: 225999
doi: 10.1042/CS20200680
doi:
Substances chimiques
Protein-Arginine N-Methyltransferases
EC 2.1.1.319
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2037-2051Informations de copyright
© 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.