Autophagy in Osteosarcoma.
Autophagy
Chemotherapy
Death
Osteosarcoma
Survival
Journal
Advances in experimental medicine and biology
ISSN: 0065-2598
Titre abrégé: Adv Exp Med Biol
Pays: United States
ID NLM: 0121103
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
9
8
2020
pubmed:
9
8
2020
medline:
22
12
2020
Statut:
ppublish
Résumé
Osteosarcoma (OS) remains a difficult disease to treat. The standard chemotherapy regimen has not improved survival for the past three decades. Resistance to chemotherapy remains a challenge and constitutes a major concern to clinical investigators. Autophagy has been recognized as a survival mechanism implicated in resistance to chemotherapy. We previously demonstrated chemotherapy to induce autophagy in OS. However, whether induction of autophagy will lead to survival or death has been the focus of many laboratories. Autophagy is a very context-dependent process, and no specific biomarker has been identified to define whether the process will lead to survival or death. In the present chapter, we present some of the mechanisms involved in the process of autophagy and summarize some of the most recent work related to autophagy in OS and the challenges encountered with the use of old and new autophagy inhibitors.
Identifiants
pubmed: 32767241
doi: 10.1007/978-3-030-43085-6_11
pmc: PMC9131842
mid: NIHMS1798205
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
167-175Subventions
Organisme : NCI NIH HHS
ID : R01 CA042992
Pays : United States
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