Echocardiographic predictors of first onset of atrial fibrillation in dogs with myxomatous mitral valve disease.
canine
left atrium
speckle tracking echocardiography
strain
Journal
Journal of veterinary internal medicine
ISSN: 1939-1676
Titre abrégé: J Vet Intern Med
Pays: United States
ID NLM: 8708660
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
31
01
2020
revised:
01
07
2020
accepted:
01
07
2020
pubmed:
9
8
2020
medline:
24
6
2021
entrez:
9
8
2020
Statut:
ppublish
Résumé
Atrial fibrillation (AF) occurs in dogs with myxomatous mitral valve disease (MMVD) as a consequence of left atrial (LA) dilatation, and it affects survival and quality of life. To evaluate the usefulness of echocardiography in predicting the first occurrence of AF in dogs with MMVD. Forty-four client-owned dogs with MMVD, 22 dogs that developed AF, and 22 dogs that maintained sinus rhythm. Retrospective observational study. Medical databases were reviewed for dogs that developed AF during the year after diagnosis of MMVD (AF group). The last echocardiographic examination obtained while still in sinus rhythm was used to derive selected variables. For each dog with AF, a control dog matched for body weight, class of heart failure, and LA dimension was selected. Echocardiographic results including LA volumes and LA speckle tracking echocardiography (STE)-derived variables were measured. Among the tested echocardiographic variables, only LA diameter (P = .03) and left ventricular internal diameter in diastole (P = .03) differed significantly between groups, whereas body weight-indexed variables of cardiac dimension as well as LA volumes and volume-derived functional variables were not different. Among the STE-derived variables, peak atrial longitudinal strain (PALS) results differed significantly between the AF group (23.8% ± 8.6%) and the control group (30.5% ± 9.6%; P = .03). A value of PALS ≤28% predicted AF occurrence with sensitivity and specificity of 0.80 and 0.65, respectively. Absolute cardiac diameters and LA STE (in particular, PALS) are useful echocardiographic predictors for the development of AF in dogs with MMVD.
Sections du résumé
BACKGROUND
BACKGROUND
Atrial fibrillation (AF) occurs in dogs with myxomatous mitral valve disease (MMVD) as a consequence of left atrial (LA) dilatation, and it affects survival and quality of life.
OBJECTIVES
OBJECTIVE
To evaluate the usefulness of echocardiography in predicting the first occurrence of AF in dogs with MMVD.
ANIMALS
METHODS
Forty-four client-owned dogs with MMVD, 22 dogs that developed AF, and 22 dogs that maintained sinus rhythm.
METHODS
METHODS
Retrospective observational study. Medical databases were reviewed for dogs that developed AF during the year after diagnosis of MMVD (AF group). The last echocardiographic examination obtained while still in sinus rhythm was used to derive selected variables. For each dog with AF, a control dog matched for body weight, class of heart failure, and LA dimension was selected. Echocardiographic results including LA volumes and LA speckle tracking echocardiography (STE)-derived variables were measured.
RESULTS
RESULTS
Among the tested echocardiographic variables, only LA diameter (P = .03) and left ventricular internal diameter in diastole (P = .03) differed significantly between groups, whereas body weight-indexed variables of cardiac dimension as well as LA volumes and volume-derived functional variables were not different. Among the STE-derived variables, peak atrial longitudinal strain (PALS) results differed significantly between the AF group (23.8% ± 8.6%) and the control group (30.5% ± 9.6%; P = .03). A value of PALS ≤28% predicted AF occurrence with sensitivity and specificity of 0.80 and 0.65, respectively.
CONCLUSIONS AND CLINICAL IMPORTANCE
CONCLUSIONS
Absolute cardiac diameters and LA STE (in particular, PALS) are useful echocardiographic predictors for the development of AF in dogs with MMVD.
Identifiants
pubmed: 32767718
doi: 10.1111/jvim.15860
pmc: PMC7517854
doi:
Types de publication
Journal Article
Observational Study, Veterinary
Langues
eng
Sous-ensembles de citation
IM
Pagination
1787-1793Informations de copyright
© 2020 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC. on behalf of the American College of Veterinary Internal Medicine.
Références
Echocardiography. 2016 Jul;33(7):1024-31
pubmed: 27277158
J Vet Intern Med. 2018 May;32(3):914-921
pubmed: 29572938
Ann Intern Med. 1968 Jul;69(1):13-20
pubmed: 5658357
Vet J. 2000 Nov;160(3):235-41
pubmed: 11061960
Am J Vet Res. 2014 Jan;75(1):59-66
pubmed: 24370247
Am J Vet Res. 2019 Apr;80(4):347-357
pubmed: 30919673
J Vet Intern Med. 2017 May;31(3):641-649
pubmed: 28455877
BMC Vet Res. 2016 Jan 05;12:3
pubmed: 26728624
Am J Cardiol. 2008 Jun 1;101(11):1626-9
pubmed: 18489941
J Am Coll Cardiol. 2003 Oct 1;42(7):1199-205
pubmed: 14522480
Eur Heart J. 2008 Jun;29(11):1397-409
pubmed: 18436560
Circulation. 1999 Jul 6;100(1):87-95
pubmed: 10393686
J Vet Intern Med. 2004 May-Jun;18(3):311-21
pubmed: 15188817
J Vet Intern Med. 2017 Mar;31(2):316-325
pubmed: 28145607
Mayo Clin Proc. 2001 May;76(5):467-75
pubmed: 11357793
Vet J. 2019 Mar;245:15-21
pubmed: 30819421
J Am Coll Cardiol. 2005 Jan 4;45(1):87-92
pubmed: 15629380
J Vet Intern Med. 2000 Jul-Aug;14(4):429-35
pubmed: 10935894
J Vet Cardiol. 2016 Jun;18(2):146-55
pubmed: 26993761
J Vet Cardiol. 2018 Dec;20(6):425-437
pubmed: 30526958
Circulation. 2001 Feb 6;103(5):769-77
pubmed: 11156892
J Vet Intern Med. 2016 Jan-Feb;30(1):51-7
pubmed: 26681398
J Am Coll Cardiol. 1998 Jul;32(1):197-204
pubmed: 9669270
Ann Noninvasive Electrocardiol. 2016 Jan;21(1):20-9
pubmed: 26523405
J Am Coll Cardiol. 2014 Feb 18;63(6):493-505
pubmed: 24291276
J Cardiol. 2011 Jan;57(1):89-94
pubmed: 20951554
J Vet Intern Med. 2018 Jan;32(1):86-92
pubmed: 29205499
J Vet Intern Med. 2019 May;33(3):1127-1140
pubmed: 30974015
J Vet Cardiol. 2017 Dec;19(6):469-479
pubmed: 29111284
Vet J. 2013 Sep;197(3):639-45
pubmed: 23838204
J Vet Intern Med. 2020 Sep;34(5):1787-1793
pubmed: 32767718
Echocardiography. 2009 Nov;26(10):1188-94
pubmed: 19765073
Eur Heart J Cardiovasc Imaging. 2012 Mar;13(3):243-50
pubmed: 22120846
Circ Cardiovasc Imaging. 2010 May;3(3):231-9
pubmed: 20133512
Heart. 2011 Dec;97(23):1982-9
pubmed: 22058287
J Vet Cardiol. 2017 Oct;19(5):462-468
pubmed: 28943125
Am J Pathol. 1977 Dec;89(3):575-604
pubmed: 145805
Can J Cardiol. 2009 Apr;25(4):e119-24
pubmed: 19340356
J Vet Cardiol. 2005 Nov;7(2):75-83
pubmed: 19083323