Sphingolipids: Regulators of azole drug resistance and fungal pathogenicity.
antifungal therapeutic target
azole resistance
ergosterol
fungal pathogenicity
sphingolipids
Journal
Molecular microbiology
ISSN: 1365-2958
Titre abrégé: Mol Microbiol
Pays: England
ID NLM: 8712028
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
04
04
2020
revised:
29
07
2020
accepted:
02
08
2020
pubmed:
9
8
2020
medline:
19
8
2021
entrez:
9
8
2020
Statut:
ppublish
Résumé
In recent years, the role of sphingolipids in pathogenic fungi, in terms of pathogenicity and resistance to azole drugs, has been a rapidly growing field. This review describes evidence about the roles of sphingolipids in azole resistance and fungal virulence. Sphingolipids can serve as signaling molecules that contribute to azole resistance through modulation of the expression of drug efflux pumps. They also contribute to azole resistance by participating in various microbial pathways such as the unfolded protein response (UPR), pH-responsive Rim pathway, and pleiotropic drug resistance (PDR) pathway. In addition, sphingolipid signaling and eisosomes also coordinately regulate sphingolipid biosynthesis in response to azole-induced membrane stress. Sphingolipids are important for fungal virulence, playing roles during growth in hosts under stressful conditions, maintenance of cell wall integrity, biofilm formation, and production of various virulence factors. Finally, we discuss the possibility of exploiting fungal sphingolipids for the development of new therapeutic strategies to treat infections caused by pathogenic fungi.
Substances chimiques
Antifungal Agents
0
Azoles
0
Sphingolipids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
891-905Informations de copyright
© 2020 John Wiley & Sons Ltd.
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