Is evaluation of non-HDL-C better than calculated LDL-C in CAD patients? MMIMSR experiences.
Coronary artery disease
Hypertriglyceridemia
LDL-C
Non-HDL-C
Receiver operating characteristic curve
Journal
Indian heart journal
ISSN: 2213-3763
Titre abrégé: Indian Heart J
Pays: India
ID NLM: 0374675
Informations de publication
Date de publication:
Historique:
received:
28
12
2019
revised:
08
03
2020
accepted:
14
05
2020
entrez:
10
8
2020
pubmed:
10
8
2020
medline:
18
3
2021
Statut:
ppublish
Résumé
The present study aimed to establish a better marker for the assessment of coronary artery disease (CAD). One hundred patients of CAD (aged 20-60 years) of both sex and patients of hypertension with symptoms of CAD were selected for the study.50 age and sex matched healthy controls were chosen for the present study. Serum total cholesterol, triglycerides and HDL-C were estimated in Simens Dimensions RxL. LDL-C, VLDL-C were calculated by Friedwald Formula while non-HDL-C was calculated by subtracting HDL-C level from total cholesterol level. The comparison of non-HDL-C and friedwald calculated LDL-C was made in terms of independent't' test, serum TG levels (TG ≤ 200 mg/dl and TG > 200 mg/dl) and area under receiver operating characteristic (AUROC) curve. The non-HDL-C levels (mean ± S.D) were higher in both test and control groups to that of the levels of friedwald calculated LDL-C. The area under receiver operating characteristic (AUROC) curve was significantly higher for non-HDL-C than for friedwald calculated LDL-C. The predictive value of non-HDL-C and friedwald calculated LDL-C were also compared in group A (serum TG ≤ 200 mg/dl) and group B (serum TG > 200 mg/dl). Non-HDL-C levels showed a significant difference in both the groups while the results were non-significant to that of friedwald calculated LDL. Thus, non-HDL-C is much specific and sensitive parameter for assessment of CAD risk. Moreover, non-HDL-C levels can also be done in non-fasting state with accuracy, thereby, it is patient friendly parameter. Therefore, the authors strongly suggest the incorporation of non-HDL-C in routine lipid profile panel.
Identifiants
pubmed: 32768019
pii: S0019-4832(20)30098-5
doi: 10.1016/j.ihj.2020.05.008
pmc: PMC7411097
pii:
doi:
Substances chimiques
Biomarkers
0
Cholesterol, HDL
0
Cholesterol, LDL
0
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
189-191Informations de copyright
Copyright © 2020 Cardiological Society of India. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of interest All authors have none to declare.
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