A new perspective on the toxicity of arsenic-contaminated soil: Tandem mass tag proteomics and metabolomics in earthworms.

Animals Arsenic / analysis Ecosystem Metabolomics Oligochaeta Proteomics Soil Soil Pollutants / analysis
As contamination Eisenia fetida Multiomics Nuclear magnetic resonance Quantitative proteomic analysis

Journal

Journal of hazardous materials
ISSN: 1873-3336
Titre abrégé: J Hazard Mater
Pays: Netherlands
ID NLM: 9422688

Informations de publication

Date de publication:
05 11 2020
Historique:
received: 10 02 2020
revised: 23 04 2020
accepted: 23 04 2020
pubmed: 10 8 2020
medline: 15 5 2021
entrez: 10 8 2020
Statut: ppublish

Résumé

The toxicity of low-level arsenic (As)-contaminated soil is not well understood. An integrated proteomic and metabolomic approach combined with morphological examination was used to investigate the potential biological toxicity of As-contaminated soil based on an exposure experiment with the earthworm Eisenia fetida. The results showed that the earthworm hindgut accumulated high As concentrations resulting in injury to the intestinal epithelia, chloragogenous tissues and coelom tissues. Furthermore, As-contaminated soil induced a significant increase in betaine levels and a decrease in dimethylglycine and myo-inositol levels in the earthworms, suggesting that the osmoregulatory metabolism of the earthworms may have been disturbed. The significantly altered levels of asparagine and dimethylglycine were proposed as potential biomarkers of As-contaminated soil. The upregulation of soluble calcium-binding proteins and profilin, the downregulation of sodium/potassium-transporting ATPase, and the proteins changes identified by gene ontology enrichment analysis confirmed that the earthworms suffered from osmotic stress. In addition, the significant changes in glycine-tRNA ligase activity and coelomic tissue injury revealed that As accumulation may disturb the earthworm immune system. This work provided new insight into the proteomic and metabolic toxicity of low-level As-contaminated soil ecosystems in earthworms, extended our knowledge of dual omics and highlighted the mechanisms underlying toxicity.

Identifiants

DOI: 10.1016/j.jhazmat.2020.122825 PMID: 32768809
pubmed: 32768809
pii: S0304-3894(20)30814-1
doi: 10.1016/j.jhazmat.2020.122825
pii:
doi:

Substances chimiques

Soil 0
Soil Pollutants 0
Arsenic N712M78A8G

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

122825

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest There are no conflicts of interest to declare.

Auteurs

Ronggui Tang (R)

Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science, Chinese Academy of Sciences, Nanjing, 210008, China; State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou, 311300, China; University of the Chinese Academy of Sciences, Beijing, 100049, China.

Ping Lan (P)

State Key Laboratory of Soil and Sustainable Agriculture, Institute of Soil Science, Chinese Academy of Sciences, Nanjing, 210008, China.

Changfeng Ding (C)

Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science, Chinese Academy of Sciences, Nanjing, 210008, China.

Junsong Wang (J)

Center for Molecular Metabolism, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, 210014, China.

Taolin Zhang (T)

Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science, Chinese Academy of Sciences, Nanjing, 210008, China.

Xingxiang Wang (X)

Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science, Chinese Academy of Sciences, Nanjing, 210008, China; University of the Chinese Academy of Sciences, Beijing, 100049, China. Electronic address: xxwang@issas.ac.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A new perspective on the toxicity of...
questionsmedicales.fr › Produits chimiques inorganiques › Éléments › Métalloïdes › Arsenic › A new perspective on the toxicity of...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › A new perspective on the toxicity of...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Métabolomique › A new perspective on the toxicity of...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Annelida › Oligochaeta › A new perspective on the toxicity of...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › A new perspective on the toxicity of...
questionsmedicales.fr › Environnement et santé publique › Environnement › Sol › A new perspective on the toxicity of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › Polluants du sol › A new perspective on the toxicity of...