Genetic Reprogramming of the Ergot Alkaloid Pathway of Metarhizium brunneum.

CRISPR-Cas Systems Ergot Alkaloids / metabolism Metabolic Networks and Pathways / genetics Metarhizium / genetics Microorganisms, Genetically-Modified / genetics
Metarhizium alkaloid secretion dihydroergot alkaloids ergot alkaloids lysergic acid

Journal

Applied and environmental microbiology
ISSN: 1098-5336
Titre abrégé: Appl Environ Microbiol
Pays: United States
ID NLM: 7605801

Informations de publication

Date de publication:
17 09 2020
Historique:
received: 25 05 2020
accepted: 30 07 2020
pubmed: 10 8 2020
medline: 2 12 2020
entrez: 10 8 2020
Statut: epublish

Résumé

Ergot alkaloids are important specialized fungal metabolites that are used to make potent pharmaceuticals for neurological diseases and disorders. Lysergic acid (LA) and dihydrolysergic acid (DHLA) are desirable lead compounds for pharmaceutical semisynthesis but are typically transient intermediates in the ergot alkaloid and dihydroergot alkaloid pathways. Previous work with

Identifiants

DOI: 10.1128/AEM.01251-20 PMID: 32769181 PMC: PMC7499049
pubmed: 32769181
pii: AEM.01251-20
doi: 10.1128/AEM.01251-20
pmc: PMC7499049
pii:
doi:

Substances chimiques

Ergot Alkaloids 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIGMS NIH HHS
ID : R15 GM114774
Pays : United States

Informations de copyright

Copyright © 2020 American Society for Microbiology.

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Auteurs

Kyle A Davis (KA)

West Virginia University, Genetics and Developmental Biology Program, Division of Plant and Soil Sciences, Morgantown, West Virginia, USA.

Jessi K Sampson (JK)

West Virginia University, Genetics and Developmental Biology Program, Division of Plant and Soil Sciences, Morgantown, West Virginia, USA.

Daniel G Panaccione (DG)

West Virginia University, Genetics and Developmental Biology Program, Division of Plant and Soil Sciences, Morgantown, West Virginia, USA danpan@wvu.edu.
ORCID: 0000-0002-4159-164X

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Classifications MeSH

questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Systèmes CRISPR-Cas › Genetic Reprogramming of the Ergot Alkaloid...
questionsmedicales.fr › Composés hétérocycliques › Alcaloïdes › Alcaloïdes de l'ergot › Genetic Reprogramming of the Ergot Alkaloid...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Genetic Reprogramming of the Ergot Alkaloid...
questionsmedicales.fr › Eucaryotes › Champignons › Deuteromycota › Metarhizium › Genetic Reprogramming of the Ergot Alkaloid...
questionsmedicales.fr › Stades d'organismes › Organismes génétiquement modifiés › Micro-organismes génétiquement modifiés › Genetic Reprogramming of the Ergot Alkaloid...