Opening the HIV envelope: potential of CD4 mimics as multifunctional HIV entry inhibitors.
Journal
Current opinion in HIV and AIDS
ISSN: 1746-6318
Titre abrégé: Curr Opin HIV AIDS
Pays: United States
ID NLM: 101264945
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
entrez:
10
8
2020
pubmed:
10
8
2020
medline:
19
8
2021
Statut:
ppublish
Résumé
Close to 2 million individuals globally become infected with HIV-1 each year and just over two-thirds will have access to life-prolonging antivirals. However, the rapid development of drug resistance creates challenges, such that generation of more effective therapies is not only warranted but a necessary endeavour. This review discusses a group of HIV-1 entry inhibitors known as CD4 mimics which exploit the highly conserved relationship between the HIV-1 envelope glycoprotein and the receptor, CD4. We review the structure/function guided evolution of these inhibitors, vital mechanistic insights that underpin broad and potent functional antagonism, recent evidence of utility demonstrated in animal and physiologically relevant in-vitro models, and current progress towards effective new-generation inhibitors. The current review highlights the promising potential of CD4 mimetics as multifunctional therapeutics.
Identifiants
pubmed: 32769632
doi: 10.1097/COH.0000000000000637
pii: 01222929-202009000-00006
pmc: PMC7737667
mid: NIHMS1651346
doi:
Substances chimiques
CD4 Antigens
0
HIV Envelope Protein gp120
0
HIV Fusion Inhibitors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
300-308Subventions
Organisme : NIAID NIH HHS
ID : R01 AI148379
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI150471
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI150322
Pays : United States
Organisme : NIGMS NIH HHS
ID : P01 GM056550
Pays : United States
Organisme : CIHR
ID : 352417
Pays : Canada
Organisme : NIAID NIH HHS
ID : U01 AI150741
Pays : United States
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