Adolescent frontal top-down neurons receive heightened local drive to establish adult attentional behavior in mice.
Action Potentials
/ physiology
Aging
/ physiology
Animals
Attention
/ physiology
Behavior, Animal
/ physiology
Channelrhodopsins
/ metabolism
Gyrus Cinguli
/ physiology
Male
Mice, Inbred C57BL
Models, Neurological
Neural Inhibition
/ physiology
Neurons
/ physiology
Presynaptic Terminals
/ physiology
Rabies
/ physiopathology
Synapses
/ physiology
Vision, Ocular
/ physiology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
07 08 2020
07 08 2020
Historique:
received:
02
07
2019
accepted:
17
07
2020
entrez:
10
8
2020
pubmed:
10
8
2020
medline:
10
9
2020
Statut:
epublish
Résumé
Frontal top-down cortical neurons projecting to sensory cortical regions are well-positioned to integrate long-range inputs with local circuitry in frontal cortex to implement top-down attentional control of sensory regions. How adolescence contributes to the maturation of top-down neurons and associated local/long-range input balance, and the establishment of attentional control is poorly understood. Here we combine projection-specific electrophysiological and rabies-mediated input mapping in mice to uncover adolescence as a developmental stage when frontal top-down neurons projecting from the anterior cingulate to visual cortex are highly functionally integrated into local excitatory circuitry and have heightened activity compared to adulthood. Chemogenetic suppression of top-down neuron activity selectively during adolescence, but not later periods, produces long-lasting visual attentional behavior deficits, and results in excessive loss of local excitatory inputs in adulthood. Our study reveals an adolescent sensitive period when top-down neurons integrate local circuits with long-range connectivity to produce attentional behavior.
Identifiants
pubmed: 32770078
doi: 10.1038/s41467-020-17787-0
pii: 10.1038/s41467-020-17787-0
pmc: PMC7414856
doi:
Substances chimiques
Channelrhodopsins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3983Subventions
Organisme : NIMH NIH HHS
ID : R01 MH119523
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA007135
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH118297
Pays : United States
Organisme : NIMH NIH HHS
ID : F30 MH111143
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH116445
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH114170
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY031009
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS105119
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH105414
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH106919
Pays : United States
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