Gait speed, life-space mobility and mild cognitive impairment in patients with coronary artery disease.
Cognitive function
Coronary artery disease
Gait speed
Life-space mobility
Mild cognitive impairment
Journal
Heart and vessels
ISSN: 1615-2573
Titre abrégé: Heart Vessels
Pays: Japan
ID NLM: 8511258
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
23
04
2020
accepted:
31
07
2020
pubmed:
10
8
2020
medline:
15
7
2021
entrez:
10
8
2020
Statut:
ppublish
Résumé
Slow gait speed and restricted life-space mobility predict cognitive decline and dementia in healthy older adults, yet the relation between gait speed or life-space mobility and cognitive function remains poorly understood in patients with coronary artery disease (CAD). We, therefore, examined the following relations: that between gait speed and cognitive function, and mild cognitive impairment (MCI) and that between life-space mobility and cognitive function, and MCI. We conducted a cross-sectional study of 240 non-dementia patients who met the study criteria from 2132 consecutive CAD patients. MCI was estimated with the Japanese version of the Montreal Cognitive Assessment (MoCA-J). Gait speed was measured to perform gait trials at the patients' usual walking pace, and life-space mobility was evaluated using the Life-Space Assessment (LSA). We investigated the relation between gait speed or life-space mobility and cognitive function by Pearson correlation analysis, whereas multivariable logistic regression analysis was conducted for detecting MCI. Gait speed and LSA scores were positively associated with the MoCA-J score (r = 0.54, p < 0.001 and r = 0.44, p < 0.001, respectively), and both were independently associated with MCI in the multivariable logistic regression analysis (odds ratio 0.007, p < 0.001, and odds ratio 0.98, p = 0.038, respectively). Cognitive impairment can be easily detected by assessment of gait speed and life-space mobility. Interventions to improve gait speed and life-space mobility may lead to the improvement of cognitive function and MCI in patients with CAD.
Identifiants
pubmed: 32770346
doi: 10.1007/s00380-020-01677-y
pii: 10.1007/s00380-020-01677-y
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
147-154Subventions
Organisme : Japan Society for the Promotion of Science (JP)
ID : JP17K01500
Références
Arai H, Ouchi Y, Toba K, Endo T, Shimokado K, Tsubota K, Matsuo S, Mori H, Yumura W, Yokode M, Rakugi H, Ohshima S (2015) Japan as the front-runner of super-aged societies: perspectives from medicine and medical care in Japan. Geriatr Gerontol Int 15:673–687
doi: 10.1111/ggi.12450
Okura Y, Ramadan MM, Ohno Y, Mitsuma W, Tanaka K, Ito M, Suzuki K, Tanabe N, Kodama M, Aizawa Y (2008) Impending epidemic: future projection of heart failure in Japan to the year 2055. Circ J 72:489–491
doi: 10.1253/circj.72.489
Sekita A, Ninomiya T, Tanizaki Y, Doi Y, Hata J, Yonemoto K, Arima H, Sasaki K, Iida M, Iwaki T, Kanba S, Kiyohara Y (2010) Trends in prevalence of Alzheimer’s disease and vascular dementia in a Japanese community: the Hisayama Study. Acta Psychiatr Scand 122:319–325
doi: 10.1111/j.1600-0447.2010.01587.x
Gauthier S, Reisberg B, Zaudig M, Petersen RC, Ritchie K, Broich K, Belleville S, Brodaty H, Bennett D, Chertkow H, Cummings JL, de Leon M, Feldman H, Ganguli M, Hampel H, Scheltens P, Tierney MC, Whitehouse P, Winblad B, International Psychogeriatric Association Expert Conference on mild cognitive impairment (2006) Mild cognitive impairment. Lancet 367:1262–1270
doi: 10.1016/S0140-6736(06)68542-5
Verghese J, Wang C, Lipton RB, Holtzer R (2013) Motoric cognitive risk syndrome and the risk of dementia. J Gerontol A Biol Sci Med Sci 68:412–418
doi: 10.1093/gerona/gls191
Verghese J, Annweiler C, Ayers E, Barzilai N, Beauchet O, Bennett DA, Bridenbaugh SA, Buchman AS, Callisaya ML, Camicioli R, Capistrant B, Chatterji S, De Cock AM, Ferrucci L, Giladi N, Guralnik JM, Hausdorff JM, Holtzer R, Kim KW, Kowal P, Kressig RW, Lim JY, Lord S, Meguro K, Montero-Odasso M, Muir-Hunter SW, Noone ML, Rochester L, Srikanth V, Wang C (2014) Motoric cognitive risk syndrome: multicountry prevalence and dementia risk. Neurology 83:718–726
doi: 10.1212/WNL.0000000000000717
Cohen JA, Verghese J, Zwerling JL (2016) Cognition and gait in older people. Maturitas 93:73–77
doi: 10.1016/j.maturitas.2016.05.005
Beauchet O, Sekhon H, Barden J, Liu-Ambrose T, Chester VL, Szturm T, Grenier S, Léonard G, Bherer L, Allali G (2018) Association of motoric cognitive risk syndrome with cardiovascular disease and risk factors: results from an original study and meta-analysis. J Alzheimers Dis 64:875–887
doi: 10.3233/JAD-180203
O’Connor ML, Edwards JD, Wadley VG, Crowe M (2010) Changes in mobility among older adults with psychometrically defined mild cognitive impairment. J Gerontol B Psychol Sci Soc Sci 65B:306–316
doi: 10.1093/geronb/gbq003
Poranen-Clark T, von Bonsdorff MB, Rantakokko M, Portegijs E, Eronen J, Kauppinen M, Eriksson JG, Rantanen T, Viljanen A (2018) Executive function and life-space mobility in old age. Aging Clin Exp Res 30:145–151
doi: 10.1007/s40520-017-0762-3
Ishihara K, Izawa KP, Kitamura M, Shimogai T, Kanejima Y, Morisawa T, Shimizu I (2020) Pinch strength is associated with the prevalence of mild cognitive impairment in patients with cardiovascular disease. J Cardiol 75:594–599
doi: 10.1016/j.jjcc.2019.12.009
Folstein MF, Folstein SE, McHugh PR (1975) “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189–198
doi: 10.1016/0022-3956(75)90026-6
Anthony JC, LeResche L, Niaz U, von Korff MR, Folstein MF (1982) Limits of the ‘Mini-Mental State’ as a screening test for dementia and delirium among hospital patients. Psychol Med 12:397–408
doi: 10.1017/S0033291700046730
Fujiwara Y, Suzuki H, Yasunaga M, Sugiyama M, Ijuin M, Sakuma N, Inagaki H, Iwasa H, Ura C, Yatomi N, Ishii K, Tokumaru AM, Homma A, Nasreddine Z, Shinkai S (2010) Brief screening tool for mild cognitive impairment in older Japanese: validation of the Japanese version of the Montreal Cognitive Assessment. Geriatr Gerontol Int 10:225–232
doi: 10.1111/j.1447-0594.2010.00585.x
Tang-Wai DF, Knopman DS, Geda YE, Edland SD, Smith GE, Ivnik RJ, Tangalos EG, Boeve BF, Petersen RC (2003) Comparison of the Short Test of Mental Status and the Mini-Mental State Examination in mild cognitive impairment. Arch Neurol 60:1777–1781
doi: 10.1001/archneur.60.12.1777
Guralnik JM, Simonsick EM, Ferrucci L, Glynn RJ, Berkman LF, Blazer DG, Scherr PA, Wallace RB (1994) A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol 49:M85–M94
doi: 10.1093/geronj/49.2.M85
Baker PS, Bodner EV, Allman RM (2003) Measuring life-space mobility in community-dwelling older adults. J Am Geriatr Soc 51:1610–1614
doi: 10.1046/j.1532-5415.2003.51512.x
Ullrich P, Werner C, Bongartz M, Kiss R, Bauer J, Hauer K (2019) Validation of a modified Life-Space Assessment in multimorbid older persons with cognitive impairment. Gerontologist 59:e66–e75
doi: 10.1093/geront/gnx214
Akobeng AK (2007) Understanding diagnostic tests 3: receiver operating characteristic curves. Acta Paediatr 96:644–647
doi: 10.1111/j.1651-2227.2006.00178.x
Fitzpatrick AL, Buchanan CK, Nahin RL, Dekosky ST, Atkinson HH, Carlson MC, Williamson JD (2007) Associations of gait speed and other measures of physical function with cognition in a healthy cohort of elderly persons. J Gerontol A Biol Sci Med Sci 62:1244–1251
doi: 10.1093/gerona/62.11.1244
Dumurgier J, Artaud F, Touraine C, Rouaud O, Tavernier B, Dufouil C, Singh-Manoux A, Tzourio C, Elbaz A (2017) Gait speed and decline in gait speed as predictors of incident dementia. J Gerontol A Biol Sci Med Sci 72:655–661
pubmed: 27302701
Semba RD, Tian Q, Carlson MC, Xue QL, Ferrucci L (2020) Motoric cognitive risk syndrome: integration of two early harbingers of dementia in older adults. Ageing Res Rev 58:101022
doi: 10.1016/j.arr.2020.101022
James BD, Boyle PA, Buchman AS, Barnes LL, Bennett DA (2011) Life space and risk of Alzheimer disease, mild cognitive impairment, and cognitive decline in old age. Am J Geriatr Psychiatry 19:961–969
doi: 10.1097/JGP.0b013e318211c219
Hsu CL, Crockett R, Chan P, Brinke LT, Doherty S, Liu-Ambrose T (2020) Functional connectivity underpinning changes in life-space mobility in older adults with mild cognitive impairment: a 12-month prospective study. Behav Brain Res 378:112216
doi: 10.1016/j.bbr.2019.112216
Lee H, Lee E, Jang IY (2020) Frailty and comprehensive geriatric assessment. J Korean Med Sci 35:e16
doi: 10.3346/jkms.2020.35.e16
Cronk BB, Johnson DK, Burns JM (2010) Alzheimer’s disease neuroimaging initiative, body mass index and cognitive decline in mild cognitive impairment. Alzheimer Dis Assoc Disord 24:126–130
doi: 10.1097/WAD.0b013e3181a6bf3f
Luck T, Luppa M, Briel S, Riedel-Heller SG (2010) Incidence of mild cognitive impairment: a systematic review. Dement Geriatr Cogn Disord 29:164–175
doi: 10.1159/000272424
Taniguchi Y, Shinkai S, Nishi M, Murayama H, Nofuji Y, Yoshida H, Fujiwara Y (2014) Nutritional biomarkers and subsequent cognitive decline among community-dwelling older Japanese: a prospective study. J Gerontol A Biol Sci Med Sci 69:1276–1283
doi: 10.1093/gerona/glt286
Iwata A, Iwatsubo T, Ihara R, Suzuki K, Matsuyama Y, Tomita N, Arai H, Ishii K, Senda M, Ito K, Ikeuchi T, Kuwano R, Matsuda H (2018) Effects of sex, educational background, and chronic kidney disease grading on longitudinal cognitive and functional decline in patients in the Japanese Alzheimer’s Disease Neuroimaging Initiative study. Alzheimers Dement (N Y) 4:765–774
doi: 10.1016/j.trci.2018.06.008
Picton JD, Marino AB, Nealy KL (2018) Benzodiazepine use and cognitive decline in the elderly. Am J Health Syst Pharm 75:e6–e12
doi: 10.2146/ajhp160381