Factors Associated With Functional Decline in Hand and Hip/Knee Osteoarthritis After One Year: Data From a Population-Based Study.
Aged
Aged, 80 and over
Antirheumatic Agents
/ therapeutic use
Cognition
Comorbidity
Disability Evaluation
Disease Progression
Emotions
Europe
/ epidemiology
Female
Functional Status
Hand Joints
/ drug effects
Hip Joint
/ drug effects
Humans
Knee Joint
/ drug effects
Longitudinal Studies
Male
Mental Health
Minimal Clinically Important Difference
Osteoarthritis, Hip
/ diagnosis
Osteoarthritis, Knee
/ diagnosis
Patient Reported Outcome Measures
Prospective Studies
Risk Assessment
Risk Factors
Time Factors
Treatment Outcome
Journal
Arthritis care & research
ISSN: 2151-4658
Titre abrégé: Arthritis Care Res (Hoboken)
Pays: United States
ID NLM: 101518086
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
16
10
2019
accepted:
30
07
2020
pubmed:
10
8
2020
medline:
6
10
2021
entrez:
10
8
2020
Statut:
ppublish
Résumé
To investigate factors that together with hand or hip/knee osteoarthritis (OA) could contribute to functional decline over a year's time in elderly individuals. The data of 1,886 individuals between ages 65 and 85 years in a prospective, observational population-based study with 12-18 months of follow-up in the context of the European Project on Osteoarthritis were analyzed. The outcome measures were self-reported hand and hip/knee functional decline, evaluated using a minimum clinically important difference of 4 on the Australian/Canadian Hand OA Index and of 2 on the Western Ontario and McMaster Universities Osteoarthritis Index hip/knee physical function subscales, both normalized to 0-100. Using regression models adjusted for sex, age, country, and education level, the baseline factors considered were clinical hand or hip/knee OA, pain, analgesic/antiinflammatory medications, comorbidities, social isolation, income, walking time, grip strength, physical activity time, and medical/social care. After a year, 453 participants were identified as having worse hand functionality and 1,389 as not worse. Hand OA, anxiety, walking time, and grip strength were risk factors for hand functional decline; pain was a confounder of the effect of hand OA. Analgesic/antiinflammatory medications mediated the combined effect of hip/knee OA plus pain on functional decline in the 554 individuals classified as having worse hip/knee functionality and the 1,291 persons who were not worse. Peripheral artery disease, obesity, and cognitive impairment were other baseline risk factors. Study findings showed that together with emotional status and chronic physical and cognitive conditions, OA affects hand and hip/knee functional decline.
Substances chimiques
Antirheumatic Agents
0
Types de publication
Journal Article
Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1343-1353Subventions
Organisme : Versus Arthritis
ID : 17702
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UP_A620_1015
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U147585827
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12011/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U147585819
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UP_A620_1014
Pays : United Kingdom
Organisme : Versus Arthritis
ID : 19583
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0400491
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U147585824
Pays : United Kingdom
Organisme : Department of Health
ID : 10/33/04
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12011/1
Pays : United Kingdom
Organisme : Arthritis Research UK
Pays : United Kingdom
Organisme : British Heart Foundation
Pays : United Kingdom
Investigateurs
T Nikolaus
(T)
R Peter
(R)
M D Denkinger
(MD)
F Herbolsheimer
(F)
S Maggi
(S)
S Zambon
(S)
F Limongi
(F)
M Noale
(M)
P Siviero
(P)
D J Deeg
(DJ)
S van der Pas
(S)
L A Schaap
(LA)
N M van Schoor
(NM)
E J Timmermans
(EJ)
A Otero
(A)
M V Castell
(MV)
M Sanchez-Martinez
(M)
R Quieipo
(R)
N L Pedersen
(NL)
R Broumandi
(R)
E M Dennison
(EM)
C Cooper
(C)
M H Edwards
(MH)
C Parsons
(C)
Informations de copyright
© 2020, American College of Rheumatology.
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