Focus on the morphogenesis, fate and the role in tumor progression of multivesicular bodies.
Amphisome
Autophagy
Cancer
Extracellular vesicles
Multivesicular body
Release
Trafficking
Journal
Cell communication and signaling : CCS
ISSN: 1478-811X
Titre abrégé: Cell Commun Signal
Pays: England
ID NLM: 101170464
Informations de publication
Date de publication:
08 08 2020
08 08 2020
Historique:
received:
09
04
2020
accepted:
27
06
2020
entrez:
11
8
2020
pubmed:
11
8
2020
medline:
11
8
2021
Statut:
epublish
Résumé
Multivesicular bodies (MVBs) are endosome organelles that are gradually attracting research attention. Initially, MVBs were considered as important components of the endosomal-lysosomal degradation pathway. In recent years, with an increase in extracellular vesicle (EV) research, the biogenesis, fate, and pathological effects of MVBs have been increasingly studied. However, the mechanisms by which MVBs are sorted to the lysosome and plasma membrane remain unclear. In addition, whether the trafficking of MVBs can determine whether exosomes are released from cells, the factors are involved in cargo loading and regulating the fate of MVBs, and the roles that MVBs play in the development of disease are unknown. Consequently, this review focuses on the mechanism of MVB biogenesis, intraluminal vesicle formation, sorting of different cargoes, and regulation of their fate. We also discuss the mechanisms of emerging amphisome-dependent secretion and degradation. In addition, we highlight the contributions of MVBs to the heterogeneity of EVs, and their important roles in cancer. Thus, we attempt to unravel the various functions of MVBs in the cell and their multiple roles in tumor progression. Video Abstract.
Identifiants
pubmed: 32771015
doi: 10.1186/s12964-020-00619-5
pii: 10.1186/s12964-020-00619-5
pmc: PMC7414566
doi:
Substances chimiques
Endosomal Sorting Complexes Required for Transport
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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