The peripartum human brain: Current understanding and future perspectives.
Female mental health
MR
Neuroimaging
PET
Peripartum depression
Reproductive psychiatry
Journal
Frontiers in neuroendocrinology
ISSN: 1095-6808
Titre abrégé: Front Neuroendocrinol
Pays: United States
ID NLM: 7513292
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
14
02
2020
revised:
30
07
2020
accepted:
31
07
2020
pubmed:
11
8
2020
medline:
22
5
2021
entrez:
11
8
2020
Statut:
ppublish
Résumé
The peripartum period offers a unique opportunity to improve our understanding of how dramatic fluctuations in endogenous ovarian hormones affect the human brain and behavior. This notwithstanding, peripartum depression remains an underdiagnosed and undertreated disorder. Here, we review recent neuroimaging findings with respect to the neuroplastic changes in the maternal brain during pregnancy and the postpartum period. We seek to provide an overview of multimodal neuroimaging designs of current peripartum depression models of hormone withdrawal, changes in monoaminergic signaling, and maladaptive neuroplasticity, which likely lead to the development of a condition that puts the lives of mother and infant at risk. We discuss the need to effectively integrate the available information on psychosocial and neurobiological risk factors contributing to individual vulnerability. Finally, we propose a systematic approach to neuroimaging the peripartum brain that acknowledges important co-morbidities and variation in disease onset.
Identifiants
pubmed: 32771399
pii: S0091-3022(20)30050-9
doi: 10.1016/j.yfrne.2020.100859
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100859Informations de copyright
Copyright © 2020. Published by Elsevier Inc.