T regulatory cells and TGF-β1: Predictors of the host response in mesh complications.
Fibrosis
Polypropylene mesh
Prolapse
T regulatory cells
TGF-β1
Journal
Acta biomaterialia
ISSN: 1878-7568
Titre abrégé: Acta Biomater
Pays: England
ID NLM: 101233144
Informations de publication
Date de publication:
01 10 2020
01 10 2020
Historique:
received:
14
05
2020
revised:
09
07
2020
accepted:
31
07
2020
pubmed:
11
8
2020
medline:
15
5
2021
entrez:
11
8
2020
Statut:
ppublish
Résumé
Polypropylene mesh is frequently used in urogynecology procedures; however, pain and mesh exposure into the vagina occur in ~10% of cases. Mesh-induced pain, which occurs with or without exposure, persists after removal in 50% of cases. Chronic pain history predicts poor response to mesh removal but only a fraction have this diagnosis. We hypothesize that mesh induced pain is correlated with fibrosis and failure to improve with a heightened inflammatory and fibrotic host response. Women undergoing mesh removal were offered participation in a mesh biorepository. Standardized questionnaires including visual analog scale (VAS) pelvic pain scores were completed at enrollment and 6 months after removal. Responders were considered those with ≥13 mm VAS improvement. 30 mesh-tissue explants were randomly selected for analysis. Samples were labeled for CD8, CD4 (T
Identifiants
pubmed: 32771596
pii: S1742-7061(20)30448-7
doi: 10.1016/j.actbio.2020.07.051
pmc: PMC8735672
mid: NIHMS1762963
pii:
doi:
Substances chimiques
Polypropylenes
0
Transforming Growth Factor beta1
0
Collagen
9007-34-5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
127-135Subventions
Organisme : NICHD NIH HHS
ID : R01 HD083383
Pays : United States
Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Am J Obstet Gynecol. 2015 Nov;213(5):668.e1-10
pubmed: 26259906
J Biol Chem. 2009 Jun 5;284(23):15980-92
pubmed: 19339244
Cell Res. 2014 Nov;24(11):1374-7
pubmed: 25112711
Scand J Gastroenterol. 2017 Dec;52(12):1427-1434
pubmed: 28927302
Am J Physiol Cell Physiol. 2010 Jan;298(1):C191-201
pubmed: 19846754
Am J Obstet Gynecol. 2010 May;202(5):481.e1-5
pubmed: 20227671
Scand J Immunol. 2009 Oct;70(4):326-36
pubmed: 19751267
Obstet Gynecol. 2014 Jun;123(6):1201-1206
pubmed: 24807341
Science. 2016 Nov 4;354(6312):572-577
pubmed: 27811267
J Biomech Eng. 2019 Feb 1;141(2):
pubmed: 30347035
J Biol Chem. 2002 Jan 11;277(2):1284-91
pubmed: 11694520
Am J Obstet Gynecol. 2016 Sep;215(3):326.e1-9
pubmed: 27001219
Neurourol Urodyn. 2019 Aug;38(6):1492-1503
pubmed: 31165519
J Surg Res. 2012 Aug;176(2):423-9
pubmed: 22099590
Am J Obstet Gynecol. 2019 Feb;220(2):187.e1-187.e8
pubmed: 30419195
Ann Emerg Med. 1996 Apr;27(4):485-9
pubmed: 8604867
Acta Biomater. 2019 Sep 15;96:203-210
pubmed: 31326666
J Pathol. 2008 Jan;214(2):199-210
pubmed: 18161745
Sex Med Rev. 2019 Oct;7(4):559-564
pubmed: 31351916
Semin Immunol. 2008 Apr;20(2):86-100
pubmed: 18162407
Int Urogynecol J. 2015 Jan;26(1):65-9
pubmed: 25011703
Female Pelvic Med Reconstr Surg. 2014 May-Jun;20(3):131-6
pubmed: 24763153
BMC Pulm Med. 2016 May 23;16(1):86
pubmed: 27215343
J Biol Chem. 1995 Sep 15;270(37):21919-27
pubmed: 7545171
Adv Healthc Mater. 2019 Feb;8(4):e1801451
pubmed: 30658015
BMJ. 2016 Jul 20;354:i3853
pubmed: 27439423
Am J Obstet Gynecol. 2016 Aug;215(2):206.e1-8
pubmed: 27094962
Plast Reconstr Surg. 2006 Apr;117(4):1214-9; discussion 1220-1
pubmed: 16582789
Ann Surg. 1992 Oct;216(4):401-6; discussion 406-8
pubmed: 1417189
Wound Repair Regen. 2008 Sep-Oct;16(5):585-601
pubmed: 19128254
Sci Rep. 2018 Nov 9;8(1):16633
pubmed: 30413733
Am Fam Physician. 2016 Mar 1;93(5):380-7
pubmed: 26926975
J Surg Res. 2002 Apr;103(2):208-14
pubmed: 11922736
Cochrane Database Syst Rev. 2013 Apr 30;(4):CD004014
pubmed: 23633316
Biochem Biophys Res Commun. 2007 Sep 7;360(4):709-14
pubmed: 17631278
Phys Med Rehabil Clin N Am. 2017 Aug;28(3):603-619
pubmed: 28676367
Adv Clin Exp Med. 2019 Oct;28(10):1301-1309
pubmed: 31430066
Am J Pathol. 2002 Sep;161(3):1039-49
pubmed: 12213733
Nat Rev Drug Discov. 2014 Jul;13(7):533-48
pubmed: 24948120
J Clin Invest. 2017 May 1;127(5):1600-1612
pubmed: 28459429
Int Urogynecol J. 2014 Apr;25(4):465-70
pubmed: 24085144
An Acad Bras Cienc. 2016 Sep;88(3):1459-70
pubmed: 27627068
Female Pelvic Med Reconstr Surg. 2017 Nov/Dec;23(6):382-386
pubmed: 28430726