Baseline Results of the West London lung cancer screening pilot study - Impact of mobile scanners and dual risk model utilisation.

Early Detection of Cancer Humans London / epidemiology Lung Neoplasms / diagnosis Mass Screening Pilot Projects Risk Assessment Tomography, X-Ray Computed
Low dose CT Lung cancer screening Risk models Risk prediction Uptake

Journal

Lung cancer (Amsterdam, Netherlands)
ISSN: 1872-8332
Titre abrégé: Lung Cancer
Pays: Ireland
ID NLM: 8800805

Informations de publication

Date de publication:
10 2020
Historique:
received: 16 06 2020
revised: 15 07 2020
accepted: 24 07 2020
pubmed: 11 8 2020
medline: 22 6 2021
entrez: 11 8 2020
Statut: ppublish

Résumé

The West London lung screening pilot aimed to identify early-stage lung cancer by targeting low-dose CT (LDCT) to high risk participants. Successful implementation of screening requires maximising participant uptake and identifying those at highest risk. As well as reporting pre-specified baseline screening metrics, additional objectives were to 1) compare participant uptake between a mobile and hospital-based CT scanner and 2) evaluate the impact on cancer detection using two lung cancer risk models. From primary care records, ever-smokers aged 60-75 were invited to a lung health check at a hospital or mobile site. Participants with PLCO Of 8366 potential participants invited, 1047/5135 (20.4 %) invitees responded to an invitation to the hospital site, and 702/3231 (21.7 %) to the mobile site (p = 0.14). The median distance travelled to the hospital site was less than to the mobile site (3.3 km vs 6.4 km, p < 0.01). Of 1159 participants eligible for a scan, 451/1159 (38.9 %) had a LLP Targeted screening is effective in detecting early-stage lung cancer. Similar levels of participant uptake at a mobile and fixed site scanner were demonstrated, indicating that uptake was driven by factors in addition to scanner location. The LLP

Identifiants

DOI: 10.1016/j.lungcan.2020.07.027 PMID: 32771715
pubmed: 32771715
pii: S0169-5002(20)30551-1
doi: 10.1016/j.lungcan.2020.07.027
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

12-19

Investigateurs

Fiona McDonald (F)
Jan Lucas Robertus (JL)
Eric Lim (E)
Joseph Barnett (J)
Jonathan Finch (J)
Paras Dalal (P)
Nadia Yousaf (N)
Armita Jamali (A)
Natallia Ivashniova (N)
Claudette Phillips (C)
Thomas Newsom-Davies (T)
Richard Lee (R)
Pritti Vaghani (P)
Sarah Whiteside (S)
Stephen Vaughan-Smith (S)

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Auteurs

Emily C Bartlett (EC)

Royal Brompton and Harefield NHS Foundation Trust, Department of Radiology, Sydney Street, London, SW3 6NP, UK.

Samuel V Kemp (SV)

Royal Brompton and Harefield NHS Foundation Trust, Department of Respiratory Medicine, Sydney Street, London, SW3 6NP, UK; National Heart and Lung Institute, Imperial College, London, SW3 6LY, UK.

Carole A Ridge (CA)

Royal Brompton and Harefield NHS Foundation Trust, Department of Radiology, Sydney Street, London, SW3 6NP, UK.

Sujal R Desai (SR)

Royal Brompton and Harefield NHS Foundation Trust, Department of Radiology, Sydney Street, London, SW3 6NP, UK; National Heart and Lung Institute, Imperial College, London, SW3 6LY, UK.

Saeed Mirsadraee (S)

Royal Brompton and Harefield NHS Foundation Trust, Department of Radiology, Sydney Street, London, SW3 6NP, UK; National Heart and Lung Institute, Imperial College, London, SW3 6LY, UK.

Jaymin B Morjaria (JB)

Royal Brompton and Harefield NHS Foundation Trust, Department of Respiratory Medicine, Harefield Hospital, Hill End Road, Harefield, UB9 6JH, UK.

Pallav L Shah (PL)

Royal Brompton and Harefield NHS Foundation Trust, Department of Respiratory Medicine, Sydney Street, London, SW3 6NP, UK; National Heart and Lung Institute, Imperial College, London, SW3 6LY, UK.

Sanjay Popat (S)

National Heart and Lung Institute, Imperial College, London, SW3 6LY, UK; Lung Unit, Royal Marsden Hospital, Fulham Road, London, SW6 3JJ, UK; Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP, UK.

Andrew G Nicholson (AG)

National Heart and Lung Institute, Imperial College, London, SW3 6LY, UK; Royal Brompton and Harefield NHS Foundation Trust, Department of Histopathology, Sydney Street, London, SW3 6NP, UK.

Alexandra J Rice (AJ)

Royal Brompton and Harefield NHS Foundation Trust, Department of Histopathology, Sydney Street, London, SW3 6NP, UK.

Simon Jordan (S)

Royal Brompton and Harefield NHS Foundation Trust, Department of Thoracic Surgery, Sydney Street, London, SW3 6NP, UK.

Sofina Begum (S)

Royal Brompton and Harefield NHS Foundation Trust, Department of Thoracic Surgery, Sydney Street, London, SW3 6NP, UK.

Aleksander Mani (A)

Royal Brompton and Harefield NHS Foundation Trust, Department of Thoracic Surgery, Sydney Street, London, SW3 6NP, UK.

Jane Derbyshire (J)

RM Partners, The West London Cancer Alliance, 5th Floor, Alliance House, 12 Caxton Street, London, SW1H 0QS, UK.

Katie Morris (K)

RM Partners, The West London Cancer Alliance, 5th Floor, Alliance House, 12 Caxton Street, London, SW1H 0QS, UK.

Michelle Chen (M)

RM Partners, The West London Cancer Alliance, 5th Floor, Alliance House, 12 Caxton Street, London, SW1H 0QS, UK.

Christine Peacock (C)

Royal Brompton and Harefield NHS Foundation Trust, Department of Radiology, Sydney Street, London, SW3 6NP, UK.

James Addis (J)

Royal Brompton and Harefield NHS Foundation Trust, Department of Radiology, Sydney Street, London, SW3 6NP, UK.

Maria Martins (M)

Respiratory Biomedical Research Unit, Royal Brompton Hospital and Harefield NHS Foundation Trust, Sydney Street, London, SW3 6NP, UK.

Stan B Kaye (SB)

RM Partners, Sycamore House, Royal Marsden NHS Foundation Trust, Downs Road, Sutton, SM2 5PT, UK.

Simon P G Padley (SPG)

Royal Brompton and Harefield NHS Foundation Trust, Department of Radiology, Sydney Street, London, SW3 6NP, UK; National Heart and Lung Institute, Imperial College, London, SW3 6LY, UK.

Anand Devaraj (A)

Royal Brompton and Harefield NHS Foundation Trust, Department of Radiology, Sydney Street, London, SW3 6NP, UK; National Heart and Lung Institute, Imperial College, London, SW3 6LY, UK. Electronic address: A.Devaraj@rbht.nhs.uk.

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Classifications MeSH

questionsmedicales.fr › Diagnostic › Diagnostic précoce › Dépistage précoce du cancer › Baseline Results of the West London lung...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Baseline Results of the West London lung...
questionsmedicales.fr › Régions géographiques › Europe › Royaume-Uni › Angleterre › Londres › Baseline Results of the West London lung...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Baseline Results of the West London lung...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pratiques en santé publique › Dépistage de masse › Baseline Results of the West London lung...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Projets pilotes › Baseline Results of the West London lung...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Appréciation des risques › Baseline Results of the West London lung...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Tomographie à rayons X › Tomodensitométrie › Baseline Results of the West London lung...