The effect of routine surveillance and decolonization on the rate of Staphylococcus aureus infections in a level IV neonatal intensive care unit.
Journal
Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
Titre abrégé: J Perinatol
Pays: United States
ID NLM: 8501884
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
10
12
2019
accepted:
22
07
2020
revised:
06
07
2020
pubmed:
11
8
2020
medline:
26
8
2021
entrez:
11
8
2020
Statut:
ppublish
Résumé
To evaluate the impact of active surveillance cultures (ASC) for Staphylococcus aureus (SA) and decolonization on the rate of infection in neonates in a neonatal intensive care unit (NICU). Using a quasi-experimental design with control groups, rates of SA infections before and after implementing weekly ASC and topical mupirocin decolonization in a level IV NICU were compared. Comparators were the rates of gram negative bloodstream infections (BSI) and of SA BSI at an affiliated NICU where the intervention was not implemented. There was a 77% (p < 0.010) reduction in rate of NICU-wide methicillin-susceptible SA (MSSA) BSI, but no significant change in rate of methicillin-resistant SA BSI, likely due to a prevalent mupirocin-resistant clone. Rates of gram negative BSI and SA BSI at an affiliated NICU did not change significantly. Weekly ASC and decolonization were associated with a unit-wide reduction in MSSA infections in a NICU.
Identifiants
pubmed: 32772050
doi: 10.1038/s41372-020-0755-5
pii: 10.1038/s41372-020-0755-5
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1644-1651Références
Hornik CP, Fort P, Clark RH, Watt K, Benjamin DK Jr, Smith PB, et al. Early and late onset sepsis in very-low-birth-weight infants from a large group of neonatal intensive care units. Early Hum Dev. 2012;88:S69–74.
doi: 10.1016/S0378-3782(12)70019-1
Hocevar SN, Edwards JR, Horan TC, Morrell GC, Iwamoto M, Lessa FC. Device-associated infections among neonatal intensive care unit patients: incidence and associated pathogens reported to the National Healthcare Safely Network, 2006–2008. Infect Control Hosp Epidemiol. 2012;33:1200–6.
doi: 10.1086/668425
Greenberg RG, Kandelfer S, Do BT, Smith PD, Stoll BJ, Bell EF, et al. Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Late-onset sepsis in extremely premature infants: 2000–2011. Pediatr Infect Dis J. 2017;36:774–9.
doi: 10.1097/INF.0000000000001570
Weiner-Lastinger LM, Abner S, Edwards JR, Kallen AJ, Karlsson M, Magill SS, et al. Antimicrobial-resistant pathogens associated with healthcare-associated infections: summary of data reported to the National Healthcare Safety Network, 2015-2017. Infect Control Hosp Epidemiol. 2020;41:19–30.
doi: 10.1017/ice.2019.297
Shane AL, Hansen NI, Stoll BJ, Bell EF, Sanchez PJ, Shankaran S, et al. Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Methicillin-resistant and susceptible Staphylococcus aureus bacteremia and meningitis in preterm infants. Pediatrics. 2012;129:e914–22.
doi: 10.1542/peds.2011-0966
Al Shaik B, Yusuf K, Sauve R. Neurodevelopmental outcomes of very low birth weight infants with neonatal sepsis: systematic review and meta-analysis. J Perinatol. 2013;33:558–64.
doi: 10.1038/jp.2012.167
Stoll BJ, Hansen NI, Adams-Chapman I, Fanaroff AA, Hintz SR, Vohr B, et al. National Institute of Child Health and Human Development Neonatal Research Network. Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection. JAMA. 2004;292:2357–65.
doi: 10.1001/jama.292.19.2357
Ericson JE, Popoola VO, Smith PB, Benjamin DK, Fowler VG, Benjamin Jr DK, et al. Burden of invasive Staphylococcus aureus infections in hospitalized infants. JAMA Pediatr. 2015;169:1105–11.
doi: 10.1001/jamapediatrics.2015.2380
Carey AJ, Duchon J, Della-Latta P, Saiman L. The epidemiology of methicillin-susceptible and methicillin-resistant Staphylococcus aureus in a neonatal intensive care unit, 2000-2007. Perinatol. 2010;30:135–9.
doi: 10.1038/jp.2009.119
Graham PL, Morel AS, Zhou J, Wu F, Della-Latta P, Rubenstein D, et al. Epidemiology of methicillin-susceptible Staphylococcus aureus in the neonatal intensive care unit. Infect Control Hosp Epidemiol. 2002;23:677–82.
doi: 10.1086/501993
Popoola VO, Colantuoni E, Suwantarat N, Pierce R, Carroll KC, Aucott SW, et al. Active surveillance cultures and decolonization to reduce Staphylococcus aureus infections in the neonatal intensive care unit. Infect Control Hosp Epidemiol. 2016;37:381–7.
doi: 10.1017/ice.2015.316
Huang YC, Chou YH, Su LH, Lien RI, Lin TY. Methicillin-resistant Staphylococcus aureus colonization and its association with infection among infants hospitalized in neonatal intensive care units. Pediatrics. 2006;118:469–74.
doi: 10.1542/peds.2006-0254
Milstone AM, Budd A, Shepard JW, Ross T, Aucott S, Carroll KC, et al. Role of decolonization in a comprehensive strategy to reduce methicillin-resistant Staphylococcus aureus infections in the neonatal intensive care unit: an observational cohort study. Infect Control Hosp Epidemiol. 2010;31:558–60.
doi: 10.1086/652449
Sakiki H, Nishioka M, Kanad K, Takahashi Y. An investigation of the risk factors of infection with methicillin-resistant Staphylococcus aureus among patients in a neonatal intensive care unit. Am J Infect Control. 2009;37:580–6.
doi: 10.1016/j.ajic.2009.02.008
Huang YC, Lien RI, Su LH, Chou YH, Lin TY. Successful control of methicillin-resistant Staphylococcus aureus in endemic neonatal intensive care units—a 7-year campaign. PloS ONE. 2011;6:e23001.
doi: 10.1371/journal.pone.0023001
Delaney HM, Wang E, Melish M. Comprehensive strategy including prophylactic mupirocin to reduce Staphylococcus aureus colonization and infection in high-risk neonates. J Perinatol. 2013;33:313–8.
doi: 10.1038/jp.2012.102
Wisgrill L, Zizka J, Unterasinger L, Rittenschober-Bӧhm J, Waldhӧr T, Makristathis A, et al. Active surveillance cultures and targeted decolonization are associated with reduced methicillin-susceptible Staphylococcus aureus infections in VLBW Infants. Neonatology. 2017;112:267–73.
doi: 10.1159/000477295
Voskertchian A, Akinboyo IC, Colantuoni E, Johnson J, Milstone AM. Association of an active surveillance and decolonization program on incidence of clinical cultures growing Staphylococcus aureus in the neonatal intensive care unit. Infect Control Hosp Epidemiol. 2018;39:882–3.
doi: 10.1017/ice.2018.81
Kotloff KL, Shirley DT, Creech CB, Frey SE, Harrison CJ, Staat M, et al. Mupirocin for Staphylococcus aureus decolonization of infants in neonatal intensive care units. Pediatrics. 2019;143:e20181565.
doi: 10.1542/peds.2018-1565
Akinboyo IC, Voskertchian A, Gorfu G, Betz JF, Ross TL, Carooll KC, et al. Epidemiology and risk factors for recurrent Staphylococcus aureus colonization following active surveillance and decolonization in the NICU. Infect Control Hosp Epidemiol. 2018;39:1334–9.
doi: 10.1017/ice.2018.223
Kleinbaum DG, Kupper LL, Morgenstern H. Epidemiologic research: principles and quantitative methods. Belmont, California: Lifetime Learning Publications; 1982.
Rosenthal A, White D, Churilla S, Brodie S, Katz KC. Optimal surveillance culture sites for detection of methicillin-resistant Staphylococcus aureus in newborns. J Clin Microbiol. 2006;44:4234–6.
doi: 10.1128/JCM.00860-06
Wisgrill L, Berger A, Waldhӧr T, Makristathis A, Assadian O, Rittenschober-Bӧhm J. Combination of nasal and expanded skin swabs enhances the detection rate of Staphylococcus aureus colonization in premature infants. Pediatr Infect Dis J. 2019;38:422–32.
doi: 10.1097/INF.0000000000002089
Gibbs K, Holzman IR. Endotracheal tube: friend or foe? bacteria, the endotracheal tube, and the impact of colonization and infection. Semin Perinatol. 2012;36:454–61.
doi: 10.1053/j.semperi.2012.06.008
Suwantarat N, Carroll KC, Tekle T, Ross T, Popoola VO, Milstone AM, et al. Low prevalence of mupirocin resistance among hospital-acquired methicillin-resistant Staphylococcus aureus isolates in a neonatal intensive care unit with an active surveillance cultures and decolonization program. Infect Control Hosp Epidemiol. 2015;36:232–4.
doi: 10.1017/ice.2014.17
Pierce R, Bryant K, Elward A, Lessler J, Milstone AM. Bacterial infections in neonates following mupirocin-based MRSA decolonization: a multicentre cohort study. Infect Control Hosp Epidemiol. 2017;38:930–6.
doi: 10.1017/ice.2017.108
Calfee DP, Salgado CD, Milstone AM, Harris AD, Kuhar DT, Moody J, et al. Society for healthcare epidemiology of America. Strategies to prevent methicillin-resistant Staphylococcus aureus transmission and infection in acute care hospitals: 2014 update. Infect Control Hosp Epidemiol. 2014;35:772–96.
doi: 10.1086/676534
Milstone AM, Voskertchian A, Koontz DW, Khamash DF, Ross T, Aucott SW, et al. Effect of treating parents colonized with Staphylococcus aureus on transmission to neonates in the intensive care unit: a randomized clinical trial. JAMA. 2020;323:319–28.
doi: 10.1001/jama.2019.20785