Interaction of Catechol-O-methyltransferase Val
COMT Val158Met
dopamine
functional connectivity
immediate verbal memory
parietal lobule
resting-state fMRI
sex
Journal
Brain and behavior
ISSN: 2162-3279
Titre abrégé: Brain Behav
Pays: United States
ID NLM: 101570837
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
14
01
2020
revised:
14
07
2020
accepted:
19
07
2020
pubmed:
11
8
2020
medline:
25
6
2021
entrez:
11
8
2020
Statut:
ppublish
Résumé
Sex differences modulate catechol-O-methyltransferase (COMT) genotype effect at a synaptic dopamine level, which influences brain function as well as cognitive performance. In this study, we investigated how COMT Val Intrinsic functional networks were extracted using independent component analysis of resting-state functional magnetic resonance imaging data from 186 healthy young COMT-genotyped participants. The association of these functional networks and memory function was tested to investigate whether the effect of COMT × sex interaction influences the association of intrinsic functional connectivity and memory performance. Quadratic curve fit estimation was used to examine the relationship between functional connectivity and speculative dopamine level among groups. COMT MM/MV carriers, relative to VV carriers, showed increased functional connectivity in left superior parietal lobule and right inferior frontal gyrus. Further, male MM/MV carriers showed significant higher mean functional connectivity in left inferior parietal lobule relative to male VV carriers and female MM/MV carriers, which was associated with worse immediate verbal recall performance. Additionally, the relationship between inferior parietal lobule functional connectivity and speculative dopamine level among groups fits the quadratic curve. These findings suggest that the interaction of COMT genotype and sex might regulate synaptic dopaminergic concentrations and influence the association of intrinsic functional connectivity and immediate verbal memory in left inferior parietal lobule.
Identifiants
pubmed: 32772512
doi: 10.1002/brb3.1784
pmc: PMC7559624
doi:
Substances chimiques
COMT protein, human
EC 2.1.1.6
Catechol O-Methyltransferase
EC 2.1.1.6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e01784Subventions
Organisme : Jiangsu Provincial Key Medical Discipline (Laboratory)
ID : ZDXKA2016020
Organisme : key medical talents of the Jiangsu province, the "13th Five-Year" health promotion project of the Jiangsu province
ID : B.Z.2016-2020
Organisme : National Natural Science Foundation of China
ID : 81720108022
Organisme : National Natural Science Foundation of China
ID : 91649116
Organisme : National Natural Science Foundation of China
ID : 81571040
Organisme : National Natural Science Foundation of China
ID : 2016-2020
Organisme : National Natural Science Foundation of China
ID : ZDXKA2016020
Organisme : the social development project of science and technology project in Jiangsu Province
ID : BE2016605
Organisme : the social development project of science and technology project in Jiangsu Province
ID : BE2017707
Organisme : project of the sixth peak of talented people
ID : WSN-138
Informations de copyright
© 2020 The Authors. Brain and Behavior published by Wiley Periodicals LLC.
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