Labeling a TCO-functionalized single domain antibody fragment with
Animals
Cell Line, Tumor
Cycloaddition Reaction
Cyclooctanes
/ chemistry
Female
Fluorine Radioisotopes
/ chemistry
Humans
Iodine Radioisotopes
/ chemistry
Mice
Mice, Nude
Ovarian Neoplasms
/ diagnosis
Positron Emission Tomography Computed Tomography
Radiopharmaceuticals
/ chemistry
Receptor, ErbB-2
/ genetics
Single-Domain Antibodies
/ chemistry
Tissue Distribution
Transplantation, Heterologous
Fluorine-18
HER2
Inverse electron-demand Diels-Alder reaction
PET imaging
Renal brush border enzyme-cleavable linker
Single domain antibody fragment (VHH, Nanobody)
Journal
Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298
Informations de publication
Date de publication:
01 09 2020
01 09 2020
Historique:
received:
13
03
2020
revised:
27
06
2020
accepted:
28
06
2020
entrez:
11
8
2020
pubmed:
11
8
2020
medline:
17
6
2021
Statut:
ppublish
Résumé
Single domain antibody fragments (sdAbs) exhibit a rapid tumor uptake and fast blood clearance amenable for labeling with
Identifiants
pubmed: 32773089
pii: S0968-0896(20)30464-8
doi: 10.1016/j.bmc.2020.115634
pmc: PMC7458057
mid: NIHMS1618825
pii:
doi:
Substances chimiques
Cyclooctanes
0
Fluorine Radioisotopes
0
Iodine Radioisotopes
0
Radiopharmaceuticals
0
Single-Domain Antibodies
0
Receptor, ErbB-2
EC 2.7.10.1
Iodine-125
GVO776611R
Fluorine-18
GZ5I74KB8G
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
115634Subventions
Organisme : NCI NIH HHS
ID : R01 CA042324
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA188177
Pays : United States
Organisme : NCI NIH HHS
ID : R37 CA042324
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest Michael R. Zalutsky is the founder of Cereius, Inc., a company that develops radiolabeling methodologies, including those described herein, for biomolecules including sdAbs. Ganesan Vaidyanathan is a consultant and shareholder of Cereius, Inc.
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