Diagnosis and Management of Gastrointestinal Neuroendocrine Neoplasms.

Gastrointestinal Neoplasms / diagnosis Gastrointestinal Tract / pathology Humans Neoplasm Staging Neuroendocrine Tumors / diagnosis
Gastrointestinal Grading Neuroendocrine carcinoma Neuroendocrine neoplasms Neuroendocrine tumor Staging WHO classification

Journal

Surgical pathology clinics
ISSN: 1875-9157
Titre abrégé: Surg Pathol Clin
Pays: United States
ID NLM: 101491209

Informations de publication

Date de publication:
Sep 2020
Historique:
entrez: 11 8 2020
pubmed: 11 8 2020
medline: 15 7 2021
Statut: ppublish

Résumé

The latest WHO classification cleanly divides gastrointestinal neuroendocrine neoplasms into neuroendocrine tumor (NET; well-differentiated, any grade) and neuroendocrine carcinoma (NEC; poorly differentiated, high-grade by definition), along with mixed neuroendocrine-non-neuroendocrine neoplasms. NECs are always aggressive, with multiple mutations; they are treated with chemotherapy. NETs have widely different presentations, behavior, and management depending on site of origin. Esophageal examples are vanishingly rare. Most gastric and appendiceal tumors are indolent, as are many colonic and rectal tumors. The duodenum is home to some unusual variants of NET, and jejunal/ileal NETs frequently metastasize, which impacts their staging and clinical management.

Identifiants

DOI: 10.1016/j.path.2020.04.002 PMID: 32773190
pubmed: 32773190
pii: S1875-9181(20)30026-X
doi: 10.1016/j.path.2020.04.002
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

377-397

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Disclosure The authors have nothing to disclose.

Auteurs

Raul S Gonzalez (RS)

Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA; Harvard Medical School, Boston, MA, USA. Electronic address: Rgonzal5@bidmc.harvard.edu.

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Classifications MeSH

questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Tumeurs gastro-intestinales › Diagnosis and Management of Gastrointestinal...
questionsmedicales.fr › Système digestif › Tube digestif › Diagnosis and Management of Gastrointestinal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Diagnosis and Management of Gastrointestinal...
questionsmedicales.fr › Diagnostic › Pronostic › Stadification tumorale › Diagnosis and Management of Gastrointestinal...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs du tissu nerveux › Tumeurs neuroectodermiques › Tumeurs neuroendocrines › Diagnosis and Management of Gastrointestinal...