Nonadherence in bipolar disorder patients: A 14-year retrospective study.
Bipolar disorders
nonadherence
prevalence
Journal
Indian journal of psychiatry
ISSN: 0019-5545
Titre abrégé: Indian J Psychiatry
Pays: India
ID NLM: 0013255
Informations de publication
Date de publication:
Historique:
received:
13
06
2019
revised:
03
10
2019
accepted:
02
01
2020
entrez:
11
8
2020
pubmed:
11
8
2020
medline:
11
8
2020
Statut:
ppublish
Résumé
Bipolar disorder is a disabling psychiatric disorder. The existing literature suggests about 41% of patients to be nonadherent. Nonadherence leads to relapses, delay in recovery besides higher inpatient care cost as well as higher global cost of the disease. Nonadherence in bipolar affective disorder (BPAD) is a complex phenomenon, its critical determinants are yet to be identified with certainty. This study aims to assess the prevalence of nonadherence in BPAD and to delineate the factors associated with it. Medical records were reviewed in this study from 2005 to 2019 at a medical college in Kerala. Patients who were diagnosed with BPAD according to International Classification of Diseases 10 and who were needing or opting for prophylaxis were included. Patients who were not taking medications for at least 1 week were termed as nonadherent. We included 150 participants in our study. To test the statistical significance of the association of categorical variables between H/O of adherence and nonadherence, Chi-square test was used. In the sample, 82.7% had at least 1 week of history of noncompliance in the past. The most common reason was poor understanding of illness by the family (56%) followed by a negative aspect of the patient toward the drug (20%). Therefore, this study concludes that though majority of the patients have a history of nonadherence of at least 1 week on long-term follow-up, it was seen that majority of the patients were more than 80% adherent to medications.
Sections du résumé
BACKGROUND
BACKGROUND
Bipolar disorder is a disabling psychiatric disorder. The existing literature suggests about 41% of patients to be nonadherent. Nonadherence leads to relapses, delay in recovery besides higher inpatient care cost as well as higher global cost of the disease. Nonadherence in bipolar affective disorder (BPAD) is a complex phenomenon, its critical determinants are yet to be identified with certainty.
AIMS
OBJECTIVE
This study aims to assess the prevalence of nonadherence in BPAD and to delineate the factors associated with it.
METHODS
METHODS
Medical records were reviewed in this study from 2005 to 2019 at a medical college in Kerala. Patients who were diagnosed with BPAD according to International Classification of Diseases 10 and who were needing or opting for prophylaxis were included. Patients who were not taking medications for at least 1 week were termed as nonadherent. We included 150 participants in our study.
RESULTS
RESULTS
To test the statistical significance of the association of categorical variables between H/O of adherence and nonadherence, Chi-square test was used. In the sample, 82.7% had at least 1 week of history of noncompliance in the past. The most common reason was poor understanding of illness by the family (56%) followed by a negative aspect of the patient toward the drug (20%).
CONCLUSION
CONCLUSIONS
Therefore, this study concludes that though majority of the patients have a history of nonadherence of at least 1 week on long-term follow-up, it was seen that majority of the patients were more than 80% adherent to medications.
Identifiants
pubmed: 32773872
doi: 10.4103/psychiatry.IndianJPsychiatry_357_19
pii: IJPsy-62-290
pmc: PMC7368454
doi:
Types de publication
Journal Article
Langues
eng
Pagination
290-294Informations de copyright
Copyright: © 2020 Indian Journal of Psychiatry.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
Value Health. 2009 Jan-Feb;12(1):118-23
pubmed: 19911444
Neuropsychobiology. 2002;46 Suppl 1:13-5
pubmed: 12571427
J Affect Disord. 2009 Jul;116(1-2):51-5
pubmed: 19101038
Psychopharmacol Bull. 1997;33(1):87-91
pubmed: 9133756
Hum Psychopharmacol. 2008 Mar;23(2):95-105
pubmed: 18058849
Psychiatr Serv. 2001 Jun;52(6):805-11
pubmed: 11376229
Neuropsychiatr Dis Treat. 2015 Apr 16;11:1077-90
pubmed: 25931823
Lancet. 1996 Aug 10;348(9024):383-6
pubmed: 8709739
Int Clin Psychopharmacol. 1995 Jan;9 Suppl 5:41-50
pubmed: 7622833
Clin Psychopharmacol Neurosci. 2018 May 31;16(2):168-175
pubmed: 29739130
J Affect Disord. 2008 Apr;107(1-3):53-62
pubmed: 17822779
J Affect Disord. 2010 Dec;127(1-3):77-83
pubmed: 20576292
Iran Red Crescent Med J. 2016 Apr 30;18(5):e25183
pubmed: 27437126
J Clin Psychiatry. 2002 May;63(5):384-90
pubmed: 12019661
Annu Rev Public Health. 2015 Mar 18;36:393-415
pubmed: 25785892
J Nerv Ment Dis. 1993 Sep;181(9):558-60
pubmed: 7902413
Am J Psychiatry. 1985 Jul;142(7):822-6
pubmed: 2861754
Rev Lat Am Enfermagem. 2009 Jul-Aug;17(4):548-56
pubmed: 19820864
J Clin Psychiatry. 2010 Dec;71(12):1689-95
pubmed: 21190640
J Clin Psychiatry. 2005 Jun;66(6):730-5; quiz 808-9
pubmed: 15960566
Acta Psychiatr Scand. 2002 Mar;105(3):164-72
pubmed: 11939969
J Postgrad Med. 2015 Oct-Dec;61(4):251-6
pubmed: 26440396
Trop Doct. 2012 Jan;42(1):28-31
pubmed: 22037517
World J Psychiatry. 2016 Dec 22;6(4):399-409
pubmed: 28078204
Bipolar Disord. 2005;7 Suppl 5:24-31
pubmed: 16225557
J Clin Psychiatry. 2010 Mar;71(3):296-303
pubmed: 20331931
Patient Prefer Adherence. 2015 Jan 13;9:87-93
pubmed: 25609930
Psychiatr Serv. 2000 Feb;51(2):216-22
pubmed: 10655006