Colocalization of Tau but Not β-Amyloid with Cortical Superficial Siderosis in a Case with Probable CAA.
Amyloid imaging
Cerebral amyloid angiopathy
Cortical superficial siderosis
Tau imaging
Journal
Case reports in neurology
ISSN: 1662-680X
Titre abrégé: Case Rep Neurol
Pays: Switzerland
ID NLM: 101517693
Informations de publication
Date de publication:
Historique:
received:
18
12
2019
accepted:
26
01
2020
entrez:
11
8
2020
pubmed:
11
8
2020
medline:
11
8
2020
Statut:
epublish
Résumé
Cortical superficial siderosis (cSS) is a common feature in patients with cerebral amyloid angiopathy (CAA). The correlation between β-amyloid and/or tau pathology and the occurrence of cSS is unclear. We report on an 80-year-old male patient who was diagnosed with probable CAA according to modified Boston criteria and underwent longitudinal magnetic resonance imaging, amyloid positron emission tomography (PET), and additional tau PET imaging. Amyloid deposition presented predominantly in the contralateral hemisphere not affected by cSS. In contrast, tau deposition was predominantly overlapping with brain regions affected by cSS. Amyloid deposition was not different in the vicinity of cSS whereas tau depositions were elevated in the vicinity of CSS-affected regions compared to non-cSS-affected brain regions. This case of probable CAA suggests that cSS may be associated with a locally elevated tau pathology but not with increased fibrillary amyloid deposition.
Identifiants
pubmed: 32774280
doi: 10.1159/000506765
pii: crn-0012-0232
pmc: PMC7383156
doi:
Types de publication
Case Reports
Langues
eng
Pagination
232-237Informations de copyright
Copyright © 2020 by S. Karger AG, Basel.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to declare. M.B. has received speaker honoraria from GE healthcare and LMI and is an advisor of LMI. All other authors have nothing to disclose.
Références
Alzheimers Dement. 2015 Aug;11(8):964-74
pubmed: 25824567
Eur J Nucl Med Mol Imaging. 2019 Sep;46(10):2178-2189
pubmed: 31264169
J Intern Med. 2004 Sep;256(3):183-94
pubmed: 15324362
Neurology. 2019 Feb 19;92(8):e792-e801
pubmed: 30674596
Neurology. 2010 Apr 27;74(17):1346-50
pubmed: 20421578
Stroke. 1987 Mar-Apr;18(2):311-24
pubmed: 3551211
Curr Atheroscler Rep. 2003 Jul;5(4):260-6
pubmed: 12793966
Eur J Nucl Med Mol Imaging. 2019 Jun;46(6):1287-1298
pubmed: 30937462
Int J Stroke. 2014 Apr;9(3):387-92
pubmed: 23834337
Neuroimage. 2006 Jul 1;31(3):1116-28
pubmed: 16545965