Functional roles of E3 ubiquitin ligases in gastric cancer.
E3 ligases
gastric cancer
signaling pathways
targeted therapy
ubiquitin
Journal
Oncology letters
ISSN: 1792-1074
Titre abrégé: Oncol Lett
Pays: Greece
ID NLM: 101531236
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
30
08
2019
accepted:
29
04
2020
entrez:
11
8
2020
pubmed:
11
8
2020
medline:
11
8
2020
Statut:
ppublish
Résumé
To date, >650 E3 ubiquitin ligases have been described in humans, including >600 really interesting new genes (RINGs), 28 homologous to E6-associated protein C-terminus (HECTs) and several RING-in-between-RINGs. They are considered key regulators and therapeutic targets of many types of human cancers, including gastric cancer (GC). Among them, some RING and HECT E3 ligases are closely related to the proliferation, infiltration and prognosis of GC. During the past few years, abnormal expressions and functions of many E3 ligases have been identified in GC. However, the functional roles of E3 ligases in GC have not been fully elucidated. The present article focuses on the functional roles of E3 ligases related to the proteasome in GC. In this comprehensive review, the latest research progress on E3 ligases involved in GC and elaborate their structure, classification, functional roles and therapeutic value in GC was summarized. Finally, 30 E3 ligases that serve essential roles in regulating the development of GC were described. Some of these ligases may serve as oncogenes or tumor suppressors in GC, whereas the pathological mechanism of others needs further study; for example, constitutive photomorphogenic 1. In conclusion, the present review demonstrated that E3 ligases are crucial tumor regulatory factors and potential therapeutic targets in GC. Therefore, more studies should focus on the therapeutic targeting of E3 ligases in GC.
Identifiants
pubmed: 32774495
doi: 10.3892/ol.2020.11883
pii: OL-0-0-11883
pmc: PMC7405480
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
22Informations de copyright
Copyright: © Wang et al.
Références
Curr Pharm Des. 2010;16(12):1427-42
pubmed: 20166982
Cell Res. 2016 Jul;26(7):838-49
pubmed: 27091432
Phytother Res. 2019 May;33(5):1562-1569
pubmed: 30932261
Mol Biol Rep. 2013 Apr;40(4):2947-53
pubmed: 23440515
Gastric Cancer. 2015 Apr;18(2):280-7
pubmed: 24748501
Pathology. 2010 Jan;42(1):93-4
pubmed: 20025491
Cancer Res. 2003 Dec 15;63(24):8606-13
pubmed: 14695171
J Cell Biochem. 2018 Nov 11;:
pubmed: 30417502
Nature. 2005 May 5;435(7038):43-57
pubmed: 15875012
Nat Struct Biol. 2003 Apr;10(4):250-5
pubmed: 12627222
Onco Targets Ther. 2018 Oct 05;11:6579-6587
pubmed: 30323630
Cancer Control. 2003 Sep-Oct;10(5):361-9
pubmed: 14581890
J Biol Chem. 2012 Mar 9;287(11):8048-59
pubmed: 22262855
Gastroenterology. 2014 Nov;147(5):1043-54
pubmed: 25046164
Immunol Lett. 2018 Oct;202:44-51
pubmed: 30099009
Curr Drug Targets. 2011 Oct;12(11):1581-94
pubmed: 21561423
Oncol Lett. 2019 Sep;18(3):3290-3294
pubmed: 31452807
EMBO J. 1998 Jan 15;17(2):368-83
pubmed: 9430629
Mini Rev Med Chem. 2018;18(2):173-183
pubmed: 28714398
Biochem Biophys Res Commun. 2001 Apr 13;282(4):1038-44
pubmed: 11352657
J Biol Chem. 2003 May 30;278(22):19682-90
pubmed: 12615916
Oncogene. 2017 Feb 23;36(8):1023-1037
pubmed: 27524417
J Exp Clin Cancer Res. 2019 Mar 5;38(1):113
pubmed: 30836988
Stem Cell Res Ther. 2017 Apr 26;8(1):98
pubmed: 28446252
Cancer Immunol Res. 2017 Jul;5(7):524-534
pubmed: 28619967
Hum Pathol. 2011 Mar;42(3):375-83
pubmed: 21190721
J Mol Biol. 2019 Jun 28;431(14):2511-2527
pubmed: 31078555
Ann Surg Oncol. 2007 Sep;14(9):2543-9
pubmed: 17597343
Int J Oncol. 2015 May;46(5):2096-106
pubmed: 25672477
Med Oncol. 2014 Nov;31(11):270
pubmed: 25280518
J Cancer Res Ther. 2013 Apr-Jun;9(2):205-9
pubmed: 23771359
Dev Comp Immunol. 2019 Aug;97:57-63
pubmed: 30910419
Cell Cycle. 2018;17(6):728-738
pubmed: 29480061
Pathol Res Pract. 2018 Aug;214(8):1218-1223
pubmed: 30006025
J Biol Chem. 2015 May 15;290(20):12941-50
pubmed: 25809483
Mol Cancer Res. 2018 Feb;16(2):286-295
pubmed: 29117943
Science. 2004 Feb 6;303(5659):844-8
pubmed: 14704432
Gene. 2019 May 25;698:50-60
pubmed: 30822475
Tumour Biol. 2015 Sep;36(10):7831-40
pubmed: 25944166
PLoS One. 2013 Dec 20;8(12):e84127
pubmed: 24376788
Hum Mol Genet. 2001 May 1;10(10):1029-38
pubmed: 11331613
FEBS Lett. 2018 Sep;592(18):3092-3100
pubmed: 30112836
J Biol Chem. 2007 Dec 7;282(49):35787-95
pubmed: 17897937
Genes Cancer. 2016 Nov;7(11-12):383-393
pubmed: 28191284
Arch Med Res. 2016 Apr;47(3):186-95
pubmed: 27393961
FEBS Lett. 2016 Feb;590(4):445-52
pubmed: 26790640
Int J Oncol. 2000 Aug;17(2):335-9
pubmed: 10891544
Nat Cell Biol. 2001 Jan;3(1):93-6
pubmed: 11146632
Biochem Biophys Res Commun. 2013 Jul 19;437(1):108-13
pubmed: 23806693
Nat Commun. 2019 Dec 16;10(1):5720
pubmed: 31844113
Biochem Biophys Res Commun. 2000 Apr 21;270(3):1093-6
pubmed: 10772955
Neoplasma. 2017;64(6):887-892
pubmed: 28895413
Med Sci Monit. 2019 May 07;25:3366-3373
pubmed: 31062766
Oncol Rep. 2017 Sep;38(3):1806-1814
pubmed: 28731194
Biosci Rep. 2019 Jan 18;39(1):
pubmed: 30389710
J Natl Cancer Inst. 2012 Nov 7;104(21):1660-72
pubmed: 23104211
Cell Oncol. 2010;32(5-6):347-59
pubmed: 20448329
Front Oncol. 2018 Aug 02;8:295
pubmed: 30116722
Br J Cancer. 2018 Feb 20;118(4):495-508
pubmed: 29235570
Biol Chem. 2018 Jan 26;399(2):127-145
pubmed: 29016349
Mol Neurobiol. 2017 Sep;54(7):5008-5016
pubmed: 27534417
Br J Cancer. 2014 Apr 15;110(8):2011-20
pubmed: 24594994
Cell. 2016 Jun 30;166(1):152-66
pubmed: 27368102
Int J Cancer. 2015 Apr 15;136(8):1921-30
pubmed: 25242378
J Pathol. 2009 Jun;218(2):248-55
pubmed: 19274672
Tumour Biol. 2014 Sep;35(9):8633-8
pubmed: 24867096
Cancer Res. 2009 Oct 15;69(20):8111-9
pubmed: 19808967
Exp Mol Med. 2017 Aug 11;49(8):e365
pubmed: 28798402
J Biol Chem. 2012 Apr 13;287(16):12975-84
pubmed: 22337872
Int J Biol Markers. 2017 May 4;32(2):e202-e209
pubmed: 28315506
In Vivo. 2018 Mar-Apr;32(2):391-396
pubmed: 29475926
J Exp Clin Cancer Res. 2018 May 2;37(1):97
pubmed: 29716622
Cell Cycle. 2013 Sep 1;12(17):2733-7
pubmed: 23966173
J Exp Clin Cancer Res. 2017 Apr 21;36(1):59
pubmed: 28431583
Oncogene. 2001 Aug 16;20(36):5067-74
pubmed: 11526493
J Cell Physiol. 2013 Dec;228(12):2285-93
pubmed: 23744514
World J Gastroenterol. 2015 Jan 21;21(3):786-93
pubmed: 25624711
Cell Physiol Biochem. 2015;35(5):1764-72
pubmed: 25832584
Cell Death Dis. 2017 Aug 10;8(8):e2994
pubmed: 28796265
Gene. 2004 Mar 17;328:135-42
pubmed: 15019993
Oncol Rep. 2017 Sep;38(3):1629-1636
pubmed: 28731191
Mol Cell. 2008 Aug 22;31(4):607-13
pubmed: 18722184
Zhongguo Yao Li Xue Bao. 1991 Sep;12(5):406-10
pubmed: 1819894
Int J Clin Exp Pathol. 2015 Feb 01;8(2):1575-83
pubmed: 25973042
Oncogene. 2001 Nov 29;20(55):8009-18
pubmed: 11753684
Tumour Biol. 2015 Feb;36(2):787-98
pubmed: 25293520
Cancer Res. 2019 Sep 1;79(17):4387-4398
pubmed: 31289136
Mol Cancer. 2018 Feb 19;17(1):24
pubmed: 29455656
J Am Chem Soc. 2019 Feb 13;141(6):2703-2712
pubmed: 30657686
Nature. 1999 Aug 12;400(6745):687-93
pubmed: 10458166
Biochem Biophys Res Commun. 2002 Jun 28;294(5):1169-76
pubmed: 12074600
World J Gastroenterol. 2008 Aug 28;14(32):5000-7
pubmed: 18763281
J BUON. 2016 Jul-Aug;21(4):867-873
pubmed: 27685907
J Mol Histol. 2013 Oct;44(5):555-63
pubmed: 23504200
Nature. 2002 Apr 18;416(6882):703-9
pubmed: 11961546
Cancer Cell. 2014 Jul 14;26(1):9-11
pubmed: 25026207
Genomics. 1999 May 15;58(1):94-7
pubmed: 10331950
Oncogene. 2018 Jan 11;37(2):148-159
pubmed: 28925398
Int J Biol Markers. 2016 Dec 23;31(4):e375-e381
pubmed: 27312587
Mol Biol (Mosk). 2019 Jul-Aug;53(4):648-653
pubmed: 31397438
Oncol Rep. 2013 Oct;30(4):1971-5
pubmed: 23933908
Cell Physiol Biochem. 2018;49(1):306-321
pubmed: 30138931
APMIS. 2008 Sep;116(9):779-84
pubmed: 19024597
Sci Rep. 2016 Apr 11;6:24218
pubmed: 27063292
J Biomed Sci. 2012 Sep 10;19:82
pubmed: 22963678
Zygote. 2018 Dec;26(6):449-456
pubmed: 30670109
Br J Cancer. 2013 Nov 12;109(10):2685-95
pubmed: 24136147
J Biol Chem. 2019 Feb 22;294(8):2651-2664
pubmed: 30587576
J Virol. 1989 Dec;63(12):5420-4
pubmed: 2585608
Cell Death Dis. 2018 Mar 2;9(3):352
pubmed: 29500411
Genes Dev. 2005 Apr 1;19(7):776-81
pubmed: 15805468
Int J Biol Sci. 2012;8(8):1168-77
pubmed: 23091414
J Toxicol Environ Health A. 2006 Aug;69(15):1399-411
pubmed: 16766476
Chin J Cancer. 2010 Jan;29(1):59-64
pubmed: 20038312
J Biol Chem. 2016 Sep 30;291(40):21085-21095
pubmed: 27432879
Br J Cancer. 2005 Mar 28;92(6):1117-25
pubmed: 15770214
Biochim Biophys Acta. 2015 Aug;1856(1):91-106
pubmed: 26116757
Cancer Cell Int. 2019 Jun 14;19:162
pubmed: 31210753
Nat Struct Mol Biol. 2014 Apr;21(4):301-7
pubmed: 24699078
Plant Cell. 2008 Sep;20(9):2307-23
pubmed: 18812498
Ann Surg Oncol. 2010 Mar;17(3):821-8
pubmed: 19898899
J Clin Invest. 2010 Dec;120(12):4493-506
pubmed: 21060154
Nat Commun. 2018 Sep 3;9(1):3569
pubmed: 30177679
EMBO J. 2013 Aug 28;32(17):2307-20
pubmed: 23912815
Front Physiol. 2019 Apr 03;10:370
pubmed: 31001145
Oncol Lett. 2018 Nov;16(5):5900-5906
pubmed: 30333866
Cancer Sci. 2011 Mar;102(3):605-13
pubmed: 21205074
Mol Biol Cell. 2018 Mar 1;29(5):542-556
pubmed: 29298839
CA Cancer J Clin. 2015 Mar;65(2):87-108
pubmed: 25651787
Int J Biol Sci. 2020 Feb 4;16(6):1071-1085
pubmed: 32140074
Nat Genet. 2014 Jun;46(6):573-82
pubmed: 24816253
J Biol Chem. 2015 Jan 16;290(3):1389-94
pubmed: 25451921
Semin Cancer Biol. 2016 Feb;36:18-32
pubmed: 26410033
Breast Cancer. 2018 Sep;25(5):529-538
pubmed: 29516369
PLoS Pathog. 2014 Sep 25;10(9):e1004358
pubmed: 25254379
Cancers (Basel). 2016 Jun 08;8(6):
pubmed: 27338477
Nat Rev Cancer. 2008 Jun;8(6):438-49
pubmed: 18500245
Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt A):1552-1561
pubmed: 29481911
FEBS Lett. 2004 Dec 3;578(1-2):21-5
pubmed: 15581609
Biochem Biophys Res Commun. 2015 Dec 25;468(4):671-6
pubmed: 26551465
Curr Opin Immunol. 2019 Jun;58:38-43
pubmed: 31063934
Nat Rev Mol Cell Biol. 2005 Jan;6(1):9-20
pubmed: 15688063
Curr Cancer Drug Targets. 2016;16(2):157-74
pubmed: 26560116
Nat Rev Mol Cell Biol. 2009 Jun;10(6):398-409
pubmed: 19436320
Int J Cancer. 2015 Apr 1;136(7):1537-45
pubmed: 25159729
Neoplasia. 2017 Apr;19(4):374-382
pubmed: 28334634
Int J Oncol. 2001 May;18(5):959-64
pubmed: 11295041
Biochem Biophys Res Commun. 2016 Sep 30;478(4):1624-9
pubmed: 27590582
Cancer Lett. 2016 Jan 1;370(1):39-55
pubmed: 26458995
Gut. 2017 Jan;66(1):31-42
pubmed: 26370108
Gene. 2015 Apr 1;559(2):164-71
pubmed: 25602436
Cell. 2018 Aug 9;174(4):856-869.e17
pubmed: 30096312
Cell Stem Cell. 2010 Jan 8;6(1):25-36
pubmed: 20085740
Oncogenesis. 2017 Jul 3;6(7):e353
pubmed: 28671676
Int J Mol Sci. 2013 Dec 16;14(12):24399-411
pubmed: 24351824
Oncotarget. 2016 May 3;7(18):26057-69
pubmed: 27036023
J Am Coll Surg. 2018 Mar;226(3):252-258
pubmed: 29277711
Cell Mol Neurobiol. 2017 Nov;37(8):1501-1509
pubmed: 28258514