Multiplex Tests for Respiratory Tract Infections: The Direct Utility of the FilmArray Respiratory Panel in Emergency Department.
Adolescent
Adult
Anti-Bacterial Agents
/ therapeutic use
Antiviral Agents
/ therapeutic use
Bordetella pertussis
/ genetics
China
/ epidemiology
Coinfection
/ diagnosis
Emergency Service, Hospital
Enterovirus
/ genetics
Enterovirus Infections
/ diagnosis
Female
Humans
Influenza A virus
/ genetics
Influenza, Human
/ diagnosis
Male
Middle Aged
Multiplex Polymerase Chain Reaction
Nasopharynx
Paramyxoviridae Infections
/ diagnosis
Picornaviridae Infections
/ diagnosis
Point-of-Care Testing
Respiratory Syncytial Virus Infections
/ diagnosis
Respiratory Tract Infections
/ diagnosis
Rhinovirus
/ genetics
Whooping Cough
/ diagnosis
Young Adult
Journal
Canadian respiratory journal
ISSN: 1916-7245
Titre abrégé: Can Respir J
Pays: Egypt
ID NLM: 9433332
Informations de publication
Date de publication:
2020
2020
Historique:
received:
25
03
2020
accepted:
29
06
2020
entrez:
11
8
2020
pubmed:
11
8
2020
medline:
8
9
2021
Statut:
epublish
Résumé
The FilmArray Respiratory Panel with multiplex targets for respiratory pathogens has been widely used and verified in clinical trials in special test settings. However, it is necessary to evaluate the panel's performance at the point of care directly, in nonspecific test settings. Patients with respiratory tract infections were enrolled from among emergency department visitors, and all steps, including the collection of specimens and testing, were performed by our clinicians. Among 270 patients, 196 (72.6%) patients were found to have one or more pathogens. For signal pathogen detection, influenza A virus had the highest rate of detection; 45 (16.7%) of the patients had two or more respiratory pathogens codetected, and most of the multiplex pathogens were rhinovirus/enterovirus codetected with Use of the FilmArray by clinical staff was successfully implemented in the emergency department for the first time in China. The FilmArray has the potential for point-of-care testing in nonspecific settings.
Sections du résumé
Background
The FilmArray Respiratory Panel with multiplex targets for respiratory pathogens has been widely used and verified in clinical trials in special test settings. However, it is necessary to evaluate the panel's performance at the point of care directly, in nonspecific test settings.
Methods
Patients with respiratory tract infections were enrolled from among emergency department visitors, and all steps, including the collection of specimens and testing, were performed by our clinicians.
Results
Among 270 patients, 196 (72.6%) patients were found to have one or more pathogens. For signal pathogen detection, influenza A virus had the highest rate of detection; 45 (16.7%) of the patients had two or more respiratory pathogens codetected, and most of the multiplex pathogens were rhinovirus/enterovirus codetected with
Conclusions
Use of the FilmArray by clinical staff was successfully implemented in the emergency department for the first time in China. The FilmArray has the potential for point-of-care testing in nonspecific settings.
Identifiants
pubmed: 32774562
doi: 10.1155/2020/6014563
pmc: PMC7397412
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antiviral Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6014563Informations de copyright
Copyright © 2020 Siyuan Yang et al.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
BMJ Open. 2019 Aug 8;9(8):e030104
pubmed: 31399462
CMAJ. 2019 Feb 11;191(6):E149-E150
pubmed: 30745398
BMC Infect Dis. 2013 Jul 09;13:309
pubmed: 23834931
Lancet Glob Health. 2019 Jan;7(1):e47-e57
pubmed: 30497986
Arch Virol. 2014 Jan;159(1):65-72
pubmed: 23881085
Lancet. 2013 Apr 20;381(9875):1380-1390
pubmed: 23369797
BMJ Open. 2018 Feb 15;8(2):e018709
pubmed: 29449294
Int J Infect Dis. 2019 Jun;83:32-39
pubmed: 30926539
J Clin Microbiol. 2018 May 25;56(6):
pubmed: 29593057
BMC Infect Dis. 2018 Jul 17;18(1):335
pubmed: 30016939
BMC Geriatr. 2019 Aug 5;19(1):210
pubmed: 31382895
Lancet Respir Med. 2017 May;5(5):401-411
pubmed: 28392237
Am J Clin Pathol. 2013 Jan;139(1):118-23
pubmed: 23270907
J Infect Dis. 2016 Feb 15;213(4):584-91
pubmed: 26180044
Rev Med Virol. 2018 Sep;28(5):e1997
pubmed: 30043515
Hum Vaccin Immunother. 2014;10(1):192-8
pubmed: 24018405
Lancet. 2019 Aug 31;394(10200):757-779
pubmed: 31257127
J Clin Microbiol. 2016 Aug;54(8):2096-103
pubmed: 27225406
Clin Microbiol Infect. 2019 Nov;25(11):1415-1421
pubmed: 31229593
Diagn Microbiol Infect Dis. 2017 Jun;88(2):115-119
pubmed: 28365060
BMC Infect Dis. 2018 Oct 11;18(1):510
pubmed: 30305033
BMC Infect Dis. 2017 Feb 6;17(1):128
pubmed: 28166743
Infect Drug Resist. 2019 Jul 30;12:2335-2341
pubmed: 31440068
BMC Infect Dis. 2017 Oct 10;17(1):671
pubmed: 29017451
Intern Emerg Med. 2020 Jun;15(4):645-654
pubmed: 31786751
J Clin Virol. 2018 Nov;108:90-95
pubmed: 30267999
Influenza Other Respir Viruses. 2020 Mar;14(2):142-149
pubmed: 31786832
Crit Care. 2015 Nov 18;19:404
pubmed: 26577540
Crit Rev Clin Lab Sci. 2011 Sep-Dec;48(5-6):217-49
pubmed: 22185616
J Microbiol Immunol Infect. 2019 Dec;52(6):920-928
pubmed: 31806539
PLoS One. 2011;6(10):e26047
pubmed: 22039434