Age-Related Maintenance of the Autophagy-Lysosomal System Is Dependent on Skeletal Muscle Type.
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2020
2020
Historique:
received:
19
05
2020
accepted:
30
06
2020
entrez:
11
8
2020
pubmed:
11
8
2020
medline:
15
5
2021
Statut:
epublish
Résumé
The skeletal muscle plays an important role in maintaining whole-body mechanics, metabolic homeostasis, and interorgan crosstalk. However, during aging, functional and structural changes such as fiber integrity loss and atrophy can occur across different species. A commonly observed hallmark of aged skeletal muscle is the accumulation of oxidatively modified proteins and protein aggregates which point to an imbalance in proteostasis systems such as degradation machineries. Recently, we showed that the ubiquitin-proteasomal system was impaired. Specifically, the proteasomal activity, which was declining in aged
Identifiants
pubmed: 32774673
doi: 10.1155/2020/4908162
pmc: PMC7396090
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4908162Informations de copyright
Copyright © 2020 Raquel Fernando et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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