Association of the mir-499 polymorphisms with oral cavity and oropharyngeal squamous cell carcinoma in an Iranian population.
Head and neck squamous cell carcinoma
microRNA
polymorphism
Journal
Dental research journal
ISSN: 1735-3327
Titre abrégé: Dent Res J (Isfahan)
Pays: Iran
ID NLM: 101471186
Informations de publication
Date de publication:
Historique:
entrez:
11
8
2020
pubmed:
11
8
2020
medline:
11
8
2020
Statut:
epublish
Résumé
Oral squamous cell carcinoma (SCC) is the most common oral malignancy. Some evidence indicated that there is a correlation between microRNA single nucleotide polymorphisms and the risk of oral cancer. The aim of the current study was to investigate the association between mir-499 polymorphism with the risk of oral cavity and oropharyngeal SCC in a subset of Iranian Population. In this case-control pilot study total of 112 participants including 56 histopathlogically confirmed oral and oropharyngeal SCC patients and 56 age- and sex-matched controls were included The mir-499 rs3746444 T/C polymorphism was detected using polymerase chain reaction-restriction fragment length polymorphism method. The comparisons of the distribution of the allele and genotype frequencies were performed using Chi-square test, and The result of the present study indicated that the frequency distribution of mir-499 was not significantly different between cases and controls ( The results of the present study indicated that the polymorphisms of mir-499 are not associated with the risk of oral and oropharyngeal SCC in Iranian population. However, further large scale studies are needed to validate our findings.
Sections du résumé
BACKGROUND
BACKGROUND
Oral squamous cell carcinoma (SCC) is the most common oral malignancy. Some evidence indicated that there is a correlation between microRNA single nucleotide polymorphisms and the risk of oral cancer. The aim of the current study was to investigate the association between mir-499 polymorphism with the risk of oral cavity and oropharyngeal SCC in a subset of Iranian Population.
MATERIALS AND METHODS
METHODS
In this case-control pilot study total of 112 participants including 56 histopathlogically confirmed oral and oropharyngeal SCC patients and 56 age- and sex-matched controls were included The mir-499 rs3746444 T/C polymorphism was detected using polymerase chain reaction-restriction fragment length polymorphism method. The comparisons of the distribution of the allele and genotype frequencies were performed using Chi-square test, and
RESULTS
RESULTS
The result of the present study indicated that the frequency distribution of mir-499 was not significantly different between cases and controls (
CONCLUSION
CONCLUSIONS
The results of the present study indicated that the polymorphisms of mir-499 are not associated with the risk of oral and oropharyngeal SCC in Iranian population. However, further large scale studies are needed to validate our findings.
Types de publication
Journal Article
Langues
eng
Pagination
174-178Informations de copyright
Copyright: © 2020 Dental Research Journal.
Déclaration de conflit d'intérêts
The authors of this manuscript declared that they have no conflicts of interest, real or perceived, and financial or non-financial in this article.
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