Polygenic Risk Scores for Subtyping of Schizophrenia.
Journal
Schizophrenia research and treatment
ISSN: 2090-2085
Titre abrégé: Schizophr Res Treatment
Pays: Egypt
ID NLM: 101576450
Informations de publication
Date de publication:
2020
2020
Historique:
received:
06
02
2020
revised:
28
05
2020
accepted:
23
06
2020
entrez:
11
8
2020
pubmed:
11
8
2020
medline:
11
8
2020
Statut:
epublish
Résumé
Schizophrenia is a complex disorder with many comorbid conditions. In this study, we used polygenic risk scores (PRSs) from schizophrenia and comorbid traits to explore consistent cluster structure in schizophrenia patients. With 10 comorbid traits, we found a stable 4-cluster structure in two datasets (MGS and SSCCS). When the same traits and parameters were applied for the patients in a clinical trial of antipsychotics, the CATIE study, a 5-cluster structure was observed. One of the 4 clusters found in the MGS and SSCCS was further split into two clusters in CATIE, while the other 3 clusters remained unchanged. For the 5 CATIE clusters, we evaluated their association with the changes of clinical symptoms, neurocognitive functions, and laboratory tests between the enrollment baseline and the end of Phase I trial. Class I was found responsive to treatment, with significant reduction for the total, positive, and negative symptoms (
Identifiants
pubmed: 32774919
doi: 10.1155/2020/1638403
pmc: PMC7396092
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1638403Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM121325
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH109706
Pays : United States
Informations de copyright
Copyright © 2020 Jingchun Chen et al.
Déclaration de conflit d'intérêts
The authors have no conflict of interest.
Références
Nat Genet. 2013 Oct;45(10):1150-9
pubmed: 23974872
EMBO J. 2013 Mar 6;32(5):617-28
pubmed: 23395906
Mol Psychiatry. 2016 Jun;21(6):758-67
pubmed: 27046643
Nat Genet. 2017 Nov;49(11):1576-1583
pubmed: 28991256
Nature. 2016 May 11;533(7604):539-42
pubmed: 27225129
JAMA Psychiatry. 2016 May 1;73(5):472-80
pubmed: 27028160
Schizophr Bull. 1996;22(3):545-55
pubmed: 8873304
Eur Psychiatry. 2002 May;17(3):155-62
pubmed: 12052576
Neuropsychopharmacology. 2006 Sep;31(9):2033-46
pubmed: 16641947
PLoS Genet. 2017 Apr 27;13(4):e1006528
pubmed: 28448500
Am J Addict. 2006 Sep-Oct;15(5):345-55
pubmed: 16966190
Biol Psychiatry. 2009 Dec 1;66(11):990-6
pubmed: 19782967
BMC Psychiatry. 2017 Jan 13;17(1):12
pubmed: 28086761
Psychiatr Q. 1990 Fall;61(3):163-78
pubmed: 2075220
Schizophr Bull. 2013 Nov;39(6):1169-72
pubmed: 24045038
Arch Gen Psychiatry. 1991 Nov;48(11):969-77
pubmed: 1747020
Int J Stroke. 2016 Aug;11(6):626-36
pubmed: 27091144
Front Neurosci. 2015 Oct 21;9:372
pubmed: 26539073
Neuroepidemiology. 2014;42(4):243-51
pubmed: 24862944
Mol Psychiatry. 2013 Jul;18(7):774-80
pubmed: 22733126
Arch Gen Psychiatry. 2009 Oct;66(10):1058-67
pubmed: 19805696
Nat Genet. 2012 Jul 22;44(8):955-9
pubmed: 22820512
Mol Psychiatry. 2008 Jun;13(6):570-84
pubmed: 18347602
Schizophr Bull. 1994;20(2):287-96
pubmed: 8085133
Nat Genet. 2015 Nov;47(11):1236-41
pubmed: 26414676
Br J Psychiatry. 2015 Jun;206(6):484-91
pubmed: 25745132
Arch Clin Neuropsychol. 1994 May;9(3):265-76
pubmed: 14589581
Nat Genet. 2011 Sep 18;43(10):969-76
pubmed: 21926974
Schizophr Res. 2009 May;110(1-3):1-23
pubmed: 19328655
Pharmacopsychiatry. 2012 May;45 Suppl 1:S31-5
pubmed: 22565232
Schizophr Bull. 2003;29(1):15-31
pubmed: 12908658
Mol Psychiatry. 2012 Mar;17(3):337-49
pubmed: 21173776
Nature. 2014 Jul 24;511(7510):421-7
pubmed: 25056061
Curr Biol. 2016 Nov 21;26(22):3083-3089
pubmed: 27818178
Schizophr Bull. 2016 Mar;42(2):279-87
pubmed: 26316594
Lancet. 2013 Sep 14;382(9896):951-62
pubmed: 23810019
Psychol Med. 2016 Oct;46(13):2717-29
pubmed: 27649341
Nat Rev Genet. 2013 Jul;14(7):483-95
pubmed: 23752797
Biol Trace Elem Res. 2018 Jan;181(1):22-30
pubmed: 28470477
Bratisl Lek Listy. 2001;102(1):5-14
pubmed: 11723675
Schizophr Bull. 2009 Mar;35(2):383-402
pubmed: 19011234
Schizophr Bull. 1987;13(2):261-76
pubmed: 3616518
Biol Psychiatry. 1999 Oct 1;46(7):882-91
pubmed: 10509171
Eur Arch Psychiatry Clin Neurosci. 2016 Aug;266(5):397-407
pubmed: 26260899
Surg Oncol Clin N Am. 2013 Oct;22(4):823-40
pubmed: 24012401
Arch Gen Psychiatry. 2003 Dec;60(12):1187-92
pubmed: 14662550
Am J Hum Genet. 2005 Sep;77(3):468-76
pubmed: 16080121
Prog Neuropsychopharmacol Biol Psychiatry. 2013 Apr 5;42:20-34
pubmed: 22122877
Nat Genet. 2010 May;42(5):441-7
pubmed: 20418890
Psychiatry Res. 2019 Jan;271:131-135
pubmed: 30472508
Schizophr Bull. 1991;17(4):609-32
pubmed: 1822677
Sci Rep. 2016 Feb 01;6:20092
pubmed: 26833182
Curr Opin Psychiatry. 2014 May;27(3):173-8
pubmed: 24613985
Schizophr Bull. 2001;27(1):115-38
pubmed: 11215541
Schizophr Bull. 1996;22(3):413-30
pubmed: 8873293
Dialogues Clin Neurosci. 2010;12(3):271-87
pubmed: 20954425
Nature. 2009 Aug 6;460(7256):748-52
pubmed: 19571811
Neuroimage Clin. 2014 Sep 18;6:229-36
pubmed: 25379435
Nature. 2009 Aug 6;460(7256):753-7
pubmed: 19571809
Schizophr Bull. 2003;29(1):45-55
pubmed: 12908660
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
JAMA Psychiatry. 2013 May;70(5):472-80
pubmed: 23467781
Int J Epidemiol. 2017 Jun 1;46(3):994-1009
pubmed: 27864402
Hum Mol Genet. 2016 Aug 1;25(15):3383-3394
pubmed: 27329760
Nucleic Acids Res. 2014 Jan;42(Database issue):D1001-6
pubmed: 24316577
Biol Psychiatry. 2013 Sep 15;74(6):400-9
pubmed: 23683390
Harv Rev Psychiatry. 2016 Mar-Apr;24(2):118-28
pubmed: 26954596
Biol Psychiatry. 2014 Feb 15;75(4):324-31
pubmed: 24286760
Schizophr Bull. 2013 Nov;39(6):1230-41
pubmed: 23720576
Am J Hum Genet. 2011 Nov 11;89(5):607-18
pubmed: 22077970