West Nile Virus-Induced Neurologic Sequelae-Relationship to Neurodegenerative Cascades and Dementias.
Alpha-synuclein
Alzheimer’s disease
Amyloid beta
Antimicrobial peptide
Neurodegenerative disease
Neurological sequelae
Parkinson’s disease
West Nile virus
Journal
Current tropical medicine reports
ISSN: 2196-3045
Titre abrégé: Curr Trop Med Rep
Pays: Switzerland
ID NLM: 101625249
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
entrez:
11
8
2020
pubmed:
11
8
2020
medline:
11
8
2020
Statut:
ppublish
Résumé
West Nile virus (WNV) emerged from Central Africa in the 1990s and is now endemic throughout much of the world. Twenty years after its introduction in the USA, it is becoming apparent that neurological impairments can persist for years following infection. Here, we review the epidemiological data in support of such long-term deficits and discuss possible mechanisms that drive these persistent manifestations. Focusing on the recently discovered antimicrobial roles of amyloid and alpha-synuclein, we connect WNV late pathology to overlapping features encountered in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. We also summarize new research on microglial activation and engulfment of neural synapses seen in recovered WNV as well as in neurodegenerative diseases, and discuss how loss of integrity of the blood-brain barrier (BBB) may exacerbate this process. Neuroinvasive viral infections such as WNV may be linked epidemiologically and mechanistically to neurodegeneration. This may open doors to therapeutic options for hitherto untreatable infectious sequelae; additionally, it may also shed light on the possible infectious etiologies of age-progressive neurodegenerative dementias.
Identifiants
pubmed: 32775145
doi: 10.1007/s40475-020-00200-7
pmc: PMC7409821
mid: NIHMS1613772
doi:
Types de publication
Journal Article
Langues
eng
Pagination
25-36Subventions
Organisme : NIAID NIH HHS
ID : K08 AI116980
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG055798
Pays : United States
Déclaration de conflit d'intérêts
Conflict of Interest The authors declare that they have no conflict of interest.
Références
Acta Neuropathol. 2016 Mar;131(3):347-63
pubmed: 26711460
J Alzheimers Dis. 2016 Oct 4;54(3):859-878
pubmed: 27392871
IDCases. 2019 May 03;17:e00551
pubmed: 31193054
Helicobacter. 2017 Oct;22(5):
pubmed: 28598012
Eur J Gastroenterol Hepatol. 2018 Jan;30(1):9-13
pubmed: 29049127
AJNR Am J Neuroradiol. 2003 Aug;24(7):1376-8
pubmed: 12917131
Nat Immunol. 2015 Mar;16(3):229-36
pubmed: 25689443
mBio. 2014 Aug 26;5(5):e01476-14
pubmed: 25161189
Neurobiol Dis. 2015 Nov;83:90-9
pubmed: 26342897
Neuron. 2018 Jul 11;99(1):64-82.e7
pubmed: 29937276
J Neuropathol Exp Neurol. 2012 May;71(5):362-81
pubmed: 22487856
Nature. 2016 Jun 22;534(7608):538-43
pubmed: 27337340
J Neurovirol. 2019 Jun;25(3):429-433
pubmed: 30903400
Ann Intern Med. 2004 Sep 7;141(5):360-5
pubmed: 15353427
Nat Immunol. 2018 Feb;19(2):151-161
pubmed: 29292385
JAMA Neurol. 2018 Oct 1;75(10):1206-1214
pubmed: 29913017
J Neurosci. 2002 Jun 1;22(11):4530-9
pubmed: 12040060
J Virol. 2005 Jun;79(12):7466-77
pubmed: 15919902
PLoS One. 2018 Jul 10;13(7):e0200200
pubmed: 29990356
J Neurol Sci. 2004 May 15;220(1-2):37-40
pubmed: 15140603
Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17140-5
pubmed: 17939996
J Virol. 2006 Jun;80(11):5383-7
pubmed: 16699018
Biochem Biophys Res Commun. 2016 Sep 16;478(2):924-8
pubmed: 27520375
Nat Rev Neurosci. 2016 Apr;17(4):201-7
pubmed: 26911435
Alzheimers Dement. 2015 Jun;11(6):593-9
pubmed: 25043910
Pediatr Neurol. 2005 Sep;33(3):217-9
pubmed: 16139740
Adv Sci (Weinh). 2019 Aug 12;6(20):1900962
pubmed: 31637161
Neuron. 2019 Mar 20;101(6):1003-1015
pubmed: 30897353
NPJ Parkinsons Dis. 2019 Sep 13;5:20
pubmed: 31531390
J Mol Neurosci. 2017 May;62(1):123-129
pubmed: 28429235
N Engl J Med. 2013 Jul 25;369(4):341-50
pubmed: 23883379
BMC Infect Dis. 2014 May 09;14:248
pubmed: 24884681
Immun Ageing. 2015 Mar 07;12:2
pubmed: 25784952
Neurology. 2014 Jul 8;83(2):e16-7
pubmed: 25002571
Nature. 2017 Jan 26;541(7638):481-487
pubmed: 28099414
Alzheimers Dement. 2018 Dec;14(12):1602-1614
pubmed: 30314800
J Neuropathol Exp Neurol. 1994 May;53(3):231-8
pubmed: 8176406
Hypertension. 2014 Mar;63(3):572-9
pubmed: 24343120
Adv Virus Res. 2003;60:273-342
pubmed: 14689697
Front Aging Neurosci. 2019 Aug 27;11:210
pubmed: 31507404
Pediatr Neurol. 2018 Mar;80:84-87
pubmed: 29398166
Cell Rep. 2019 Aug 20;28(8):2111-2123.e6
pubmed: 31433986
Emerg Infect Dis. 2005 Aug;11(8):1174-9
pubmed: 16102303
Med Microbiol Immunol. 1998 Jun;187(1):23-42
pubmed: 9749980
Front Microbiol. 2016 Jun 20;7:959
pubmed: 27379085
PLoS One. 2014 Jul 02;9(7):e101364
pubmed: 24988208
Curr Pharm Des. 2012;18(25):3645-8
pubmed: 22574977
Pediatr Neurol. 2018 Aug;85:16-20
pubmed: 30343688
N Engl J Med. 2014 Apr 10;370(15):1460
pubmed: 24716687
JAMA. 2013 Jul 17;310(3):308-15
pubmed: 23860989
Sci Transl Med. 2016 May 25;8(340):340ra72
pubmed: 27225182
J Neurosci. 2014 Nov 12;34(46):15490-6
pubmed: 25392516
Nat Commun. 2019 May 27;10(1):2331
pubmed: 31133680
Front Microbiol. 2017 Feb 14;8:213
pubmed: 28261172
Arch Neurol. 2003 Oct;60(10):1448-52
pubmed: 14568817
JAMA. 2003 Jul 23;290(4):511-5
pubmed: 12876094
Front Neurol. 2018 Mar 27;9:111
pubmed: 29636722
Nat Rev Neurol. 2018 Mar;14(3):133-150
pubmed: 29377008
Science. 2016 May 6;352(6286):712-716
pubmed: 27033548
F1000Res. 2018 Mar 19;7:338
pubmed: 29623197
Mov Disord. 2010 Jul 15;25(9):1124-30
pubmed: 20629127
Immunity. 2017 Sep 19;47(3):566-581.e9
pubmed: 28930663
J Virol. 2006 Dec;80(24):12060-9
pubmed: 17035323
Lancet. 1997 Jan 25;349(9047):241-4
pubmed: 9014911
Nat Rev Neurol. 2013 Feb;9(2):106-18
pubmed: 23296339
N Engl J Med. 2017 Nov 9;377(19):1878-1886
pubmed: 29117489
J Virol. 2007 Aug;81(15):8157-64
pubmed: 17522198
FASEB J. 2010 Feb;24(2):548-59
pubmed: 19825975
Cell Rep. 2019 Jul 23;28(4):1103-1116.e4
pubmed: 31340147
Biomed Res Int. 2015;2015:376230
pubmed: 25866777
AJNR Am J Neuroradiol. 2005 Feb;26(2):289-97
pubmed: 15709126
J Cell Biol. 2018 Feb 5;217(2):459-472
pubmed: 29196460
Neuron. 2015 Feb 4;85(3):519-33
pubmed: 25619653
Neurology. 2009 Dec 15;73(24):2061-70
pubmed: 19923550
Neuron. 1991 Apr;6(4):487-98
pubmed: 1673054
J Parkinsons Dis. 2018;8(s1):S47-S51
pubmed: 30584163
Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):17872-9
pubmed: 20923878
mBio. 2019 Aug 6;10(4):
pubmed: 31387911
Sci Adv. 2019 Jan 23;5(1):eaau3333
pubmed: 30746447
Immunity. 2017 Jun 20;46(6):957-967
pubmed: 28636962
Virology. 2009 Mar 15;385(2):425-33
pubmed: 19135695
Nature. 2017 Jun 29;546(7660):656-661
pubmed: 28636593
Clin Infect Dis. 2006 Sep 15;43(6):723-30
pubmed: 16912946
J Clin Neuromuscul Dis. 2011 Mar;12(3):113-7
pubmed: 21321488
Am J Trop Med Hyg. 2006 Oct;75(4):691-6
pubmed: 17038696
J Clin Exp Neuropsychol. 2010 Jan;32(1):81-7
pubmed: 19513920
Viral Immunol. 2019 Jan/Feb;32(1):38-47
pubmed: 30222521
Annu Rev Med. 2018 Jan 29;69:437-449
pubmed: 29106805
N Engl J Med. 2014 Jan 23;370(4):311-21
pubmed: 24450890
Viral Immunol. 2003;16(3):259-78
pubmed: 14583143
Immunol Cell Biol. 2017 Oct;95(9):843-853
pubmed: 28682305
J Alzheimers Dis. 2004 Dec;6(6):639-49; discussion 673-81
pubmed: 15665404
Neurotoxicol Teratol. 1996 Jul-Aug;18(4):499-504
pubmed: 8866544
J Immunol. 2010 May 1;184(9):5333-43
pubmed: 20368278
Mol Neurodegener. 2013 Jun 21;8:19
pubmed: 23800361
J Neurol Neurosurg Psychiatry. 1998 Jul;65(1):29-33
pubmed: 9667557
J Med Virol. 2016 Nov;88(11):1856-61
pubmed: 27061922
Sci Rep. 2018 Jul 26;8(1):11258
pubmed: 30050078
Mol Neurodegener. 2019 Apr 5;14(1):16
pubmed: 30953527
Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1896-E1905
pubmed: 29437957
J Alzheimers Dis. 2018;62(4):1495-1506
pubmed: 29504537
Transpl Int. 2007 Sep;20(9):800-3
pubmed: 17630998
J Virol. 2011 Oct;85(20):10682-90
pubmed: 21849461
J Virol. 2003 Dec;77(24):13203-13
pubmed: 14645577
Mol Neurodegener. 2012 Jul 29;7:36
pubmed: 22838967
AJNR Am J Neuroradiol. 2005 Sep;26(8):1986-95
pubmed: 16155147
AIDS. 2005 Mar 4;19(4):407-11
pubmed: 15750394
Nat Commun. 2017 Nov 15;8(1):1522
pubmed: 29142315
BMC Immunol. 2011 Jan 20;12:6
pubmed: 21251256
Neuron. 2018 Dec 19;100(6):1527-1532
pubmed: 30571943
Mol Neurodegener. 2011 Feb 16;6:16
pubmed: 21324189
PLoS One. 2016 Jun 28;11(6):e0158364
pubmed: 27352145
J Med Virol. 1991 Apr;33(4):224-7
pubmed: 1649907
Mov Disord. 2019 Aug;34(8):1154-1163
pubmed: 31211448
Nat Med. 2017 Sep 8;23(9):1018-1027
pubmed: 28886007
J Neuropsychol. 2008 Sep;2(2):477-99
pubmed: 19824176
Alzheimers Dement. 2015 Dec;11(12):1407-1416
pubmed: 25936935
J Neurosci. 2010 Jul 7;30(27):9038-50
pubmed: 20610738
J Alzheimers Dis. 2016;50(4):1227-41
pubmed: 26836158
J Neurovirol. 2018 Aug;24(4):506-513
pubmed: 29696579
Stroke. 2002 Aug;33(8):2115-22
pubmed: 12154274
Epidemiol Infect. 2013 Mar;141(3):591-5
pubmed: 22640592
J Korean Med Sci. 2015 Mar;30(3):343-5
pubmed: 25729260
J Med Case Rep. 2011 May 25;5:204
pubmed: 21612601
J Virol. 2018 Jul 31;92(16):
pubmed: 29899084
J Virol. 2015 Dec 30;90(6):2767-82
pubmed: 26719256
Am J Med. 2018 Sep;131(9):1064-1066
pubmed: 29571980
Front Cell Infect Microbiol. 2019 Feb 06;9:8
pubmed: 30788291
Neuron. 2015 Jan 7;85(1):101-115
pubmed: 25533482
J Pharmacovigil. 2014 Jun;2(2):125
pubmed: 25632404
Science. 2018 Dec 14;362(6420):1250-1251
pubmed: 30545877
Viruses. 2013 Sep 20;5(9):2298-310
pubmed: 24061543
J Neurosci. 2014 Jun 18;34(25):8546-56
pubmed: 24948809
Diagn Microbiol Infect Dis. 2014 Feb;78(2):132-6
pubmed: 24316017
Emerg Infect Dis. 2004 Aug;10(8):1405-11
pubmed: 15496241
Jpn J Infect Dis. 1999 Jun;52(3):89-98
pubmed: 10507986
Emerg Infect Dis. 2007 Dec;13(12):1918-20
pubmed: 18258047
Nephrol Dial Transplant. 2007 Feb;22(2):662-3
pubmed: 17012739
Nature. 2019 Jul;571(7766):565-569
pubmed: 31316206
Emerg Infect Dis. 2006 Aug;12(8):1260-2
pubmed: 16965710
PLoS One. 2010 Mar 03;5(3):e9505
pubmed: 20209079
Neuron. 2012 May 24;74(4):691-705
pubmed: 22632727
Handb Clin Neurol. 2016;133:39-59
pubmed: 27112670
J Alzheimers Dis. 2019;67(1):211-220
pubmed: 30636735
Nat Neurosci. 2019 Aug;22(8):1276-1288
pubmed: 31235930
Nat Neurosci. 2018 Oct;21(10):1318-1331
pubmed: 30250261
J La State Med Soc. 2005 Jan-Feb;157(1):42-6
pubmed: 15887668
Am J Transplant. 2004 May;4(5):830-3
pubmed: 15084182
Science. 2019 Nov 29;366(6469):1134-1139
pubmed: 31727856
Mikrobiyol Bul. 2013 Jan;47(1):164-72
pubmed: 23390915
PLoS One. 2014 Jul 23;9(7):e102953
pubmed: 25054656
Nat Rev Microbiol. 2013 Feb;11(2):115-28
pubmed: 23321534
Alzheimers Dement. 2019 Jan;15(1):17-24
pubmed: 30243772
PLoS One. 2010 May 14;5(5):e10649
pubmed: 20498839