Identification of Torque Teno Virus/Torque Teno-Like Minivirus in the Cervical Lymph Nodes of Kikuchi-Fujimoto Lymphadenitis Patients (Histiocytic Necrotizing Lymphadenitis): A Possible Key to Idiopathic Disease.
Histiocytic necrotizing lymphadenitis
Kikuchi-Fujimoto disease
Lymphadenitis
Torque teno virus/torque teno minivirus
Journal
Biomedicine hub
ISSN: 2296-6870
Titre abrégé: Biomed Hub
Pays: Switzerland
ID NLM: 101692630
Informations de publication
Date de publication:
Historique:
received:
07
12
2019
accepted:
11
02
2020
entrez:
11
8
2020
pubmed:
11
8
2020
medline:
11
8
2020
Statut:
epublish
Résumé
Kikuchi-Fujimoto disease (KFD) is rare, and many infectious agents have been suspected for its etiology. This report presents an interesting case of KFD found with torque teno virus/torque teno minivirus (TTV/TTMV), which closely resembles the circovirus that causes necrotizing lymphadenitis in pigs. Three Korean patients showed several enlarged lymph nodes in their neck. Quantitative polymerase chain reaction (qPCR) and subsequent DNA sequencing for TTV/TTMV using formalin-fixed paraffin-embedded tissue were performed. Histologic examination demonstrated typical features of KFD. qPCR showed successful amplification of TTV/TTMV, and DNA sequencing confirmed the results. It is the first report of TTV/TTMV presence in three patients with KFD.
Identifiants
pubmed: 32775328
doi: 10.1159/000506501
pii: bmh-0005-0001
pmc: PMC7383298
doi:
Types de publication
Case Reports
Langues
eng
Pagination
1-5Informations de copyright
Copyright © 2020 by S. Karger AG, Basel.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to declare.
Références
Int J Pediatr Otorhinolaryngol. 2014 Nov;78(11):1890-7
pubmed: 25200851
Lancet. 1998 Jul 18;352(9123):195-7
pubmed: 9683209
Am J Clin Pathol. 2004 Jul;122(1):141-52
pubmed: 15272543
Clin Rheumatol. 2020 Mar;39(3):925-931
pubmed: 31782015
Respirology. 2008 Mar;13(2):263-9
pubmed: 18339026
Virology. 2003 Feb 15;306(2):324-33
pubmed: 12642105
J Clin Virol. 2000 Jun;17(1):1-3
pubmed: 10814932
Biochem Biophys Res Commun. 1997 Dec 8;241(1):92-7
pubmed: 9405239
Vet J. 2005 May;169(3):326-36
pubmed: 15848776
Rev Med Virol. 2007 Jan-Feb;17(1):45-57
pubmed: 17146841
J Virol Methods. 2002 Jun;104(1):59-67
pubmed: 12020793