Urinary Sodium-to-Potassium Ratio and Blood Pressure in CKD.
blood pressure
chronic kidney disease
potassium
salt
sodium
Journal
Kidney international reports
ISSN: 2468-0249
Titre abrégé: Kidney Int Rep
Pays: United States
ID NLM: 101684752
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
27
09
2019
revised:
11
05
2020
accepted:
18
05
2020
entrez:
11
8
2020
pubmed:
11
8
2020
medline:
11
8
2020
Statut:
epublish
Résumé
In the general population, urinary sodium-to-potassium (uNa/K) ratio associates more strongly with high blood pressure (BP) than either urinary sodium or potassium alone. Whether this is also the case among patients with chronic kidney disease (CKD) is unknown. We studied the associations of spot urine sodium-to-creatinine (uNa/Cr), potassium-to-creatinine (uK/Cr), and uNa/K ratios with a single office BP reading in 1660 patients with moderate to severe CKD at inclusion in the CKD-REIN cohort. Patients' median age was 68 (interquartile range [IQR], 59-76) years; most were men (65%), had moderate CKD (57%), and albuminuria (72%). Mean systolic and diastolic BP was 142/78 mm Hg. Spot uNa/Cr and uNa/K ratios were positively associated with systolic, mean arterial, and pulse pressures. The mean adjusted difference in systolic BP between the highest and the lowest quartile (Q4 vs In patients with CKD, higher urinary sodium excretion is associated with higher BP, but unlike in general population, lower potassium excretion is not. Urinary Na/K does not add significant value in assessing high BP risk, except perhaps for hypertension control assessment.
Identifiants
pubmed: 32775823
doi: 10.1016/j.ekir.2020.05.025
pii: S2468-0249(20)31286-9
pmc: PMC7403539
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1240-1250Investigateurs
Thierry Hannedouche
(T)
Bruno Moulin
(B)
Sébastien Mailliez
(S)
Gaétan Lebrun
(G)
Eric Magnant
(E)
Gabriel Choukroun
(G)
Benjamin Deroure
(B)
Adeline Lacraz
(A)
Guy Lambrey
(G)
Jean Philippe Bourdenx
(JP)
Marie Essig
(M)
Thierry Lobbedez
(T)
Raymond Azar
(R)
Hacène Sekhri
(H)
Mustafa Smati
(M)
Mohamed Jamali
(M)
Alexandre Klein
(A)
Michel Delahousse
(M)
Christian Combe
(C)
Séverine Martin
(S)
Isabelle Landru
(I)
Eric Thervet
(E)
Ziad A Massy
(ZA)
Philippe Lang
(P)
Xavier Belenfant
(X)
Pablo Urena
(P)
Carlos Vela
(C)
Luc Frimat
(L)
Dominique Chauveau
(D)
Viktor Panescu
(V)
Christian Noel
(C)
François Glowacki
(F)
Maxime Hoffmann
(M)
Maryvonne Hourmant
(M)
Dominique Besnier
(D)
Angelo Testa
(A)
François Kuentz
(F)
Philippe Zaoui
(P)
Charles Chazot
(C)
Laurent Juillard
(L)
Stéphane Burtey
(S)
Adrien Keller
(A)
Nassim Kamar
(N)
Denis Fouque
(D)
Maurice Laville
(M)
Informations de copyright
© 2020 International Society of Nephrology. Published by Elsevier Inc.
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