Current perspectives on the dysregulated microRNAs in gastric cancer.
Angiogenesis
Gastric cancer
Invasion
Migration
Proliferation
miRNAs
Journal
Molecular biology reports
ISSN: 1573-4978
Titre abrégé: Mol Biol Rep
Pays: Netherlands
ID NLM: 0403234
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
20
05
2020
accepted:
02
08
2020
pubmed:
11
8
2020
medline:
19
5
2021
entrez:
11
8
2020
Statut:
ppublish
Résumé
Since gastric cancer (GC) is diagnosed at advanced stages, the survival rate is low in affected people. In this regard, investigating the mechanisms underlying GC development, are so critical. MiRNAs, which are small non coding RNAs, as a post transcriptional repressor, regulate expression of target genes by stimulating breakage or transcription suppression of their targets therefore aberrant expression of miRNAs leading to GC carcinogenesis. In the last decades, there have been various studies approving the pivotal role of miRNAs in various phases of GC development including cancer initiation, proliferation, migration, invasion, metastasis, angiogenesis, apoptosis, and drug resistance. Therefore, the present review aimed at summarizing the dysregulated miRNAs which contribute to various cellular and developmental mechanisms such as, proliferation, apoptosis, invasion, migration, and angiogenesis. Moreover, it provides an overview on novel miRNAs involved in drug resistance and circular miRNAs as cancer biomarkers. Thereafter, it is hoped that the present study will shed more light on diagnostic and prognostic biomarkers of GC, and potential GC treatments based on miRNAs.
Identifiants
pubmed: 32776162
doi: 10.1007/s11033-020-05720-z
pii: 10.1007/s11033-020-05720-z
doi:
Substances chimiques
Biomarkers, Tumor
0
MicroRNAs
0
RNA, Neoplasm
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
7253-7264Références
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