Antiviral effects of statins.

Animals Antiviral Agents / immunology Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / immunology Virus Diseases / drug therapy Viruses / drug effects
Cholesterol Infection Pleiotropic Statins Virus

Journal

Progress in lipid research
ISSN: 1873-2194
Titre abrégé: Prog Lipid Res
Pays: England
ID NLM: 7900832

Informations de publication

Date de publication:
07 2020
Historique:
received: 01 06 2020
revised: 25 07 2020
accepted: 27 07 2020
pubmed: 11 8 2020
medline: 12 1 2021
entrez: 11 8 2020
Statut: ppublish

Résumé

Introducing statins as possible widely-available drugs for the treatment of viral infections requires an in depth review of their antiviral properties. Despite some inconsistency, a large body of literature data from experimental and clinical studies suggest that statins may have a role in the treatment of viral infections due to their immunomodulatory properties as well as their ability to inhibit viral replication. In the present review, the role that statins may play while interacting with the immune system during viral infections and the possible inhibitory effects of statins on different stages of virus cell cycle (i.e., from fusion with host cell membranes to extracellular release) and subsequent virus transmission are described. Specifically, cholesterol-dependent and cholesterol-independent mechanisms of the antiviral effects of statins are reported.

Identifiants

DOI: 10.1016/j.plipres.2020.101054 PMID: 32777243
pubmed: 32777243
pii: S0163-7827(20)30034-5
doi: 10.1016/j.plipres.2020.101054
pii:
doi:

Substances chimiques

Antiviral Agents 0
Hydroxymethylglutaryl-CoA Reductase Inhibitors 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

101054

Informations de copyright

Copyright © 2020. Published by Elsevier Ltd.

Auteurs

Armita M Gorabi (AM)

Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

Nasim Kiaie (N)

Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

Vanessa Bianconi (V)

Unit of Internal Medicine, Department of Medicine, University of Perugia, Perugia, Italy.

Tannaz Jamialahmadi (T)

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Food Science and Technology, Quchan Branch, Islamic Azad University, Quchan, Iran; Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Khalid Al-Rasadi (K)

Department of Clinical Biochemistry, Sultan Qaboos University Hospital, Muscat, Oman.

Thomas P Johnston (TP)

Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA.

Matteo Pirro (M)

Unit of Internal Medicine, Department of Medicine, University of Perugia, Perugia, Italy. Electronic address: matteo.pirro@unipg.it.

Amirhossein Sahebkar (A)

Halal Research Center of IRI, FDA, Tehran, Iran; Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland. Electronic address: sahebkara@mums.ac.ir.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Antiviral effects of statins.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Antiviral effects of statins.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Antiviral effects of statins.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents régulateurs du métabolisme des lipides › Hypolipémiants › Anticholestérolémiants › Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase › Antiviral effects of statins.
questionsmedicales.fr › Infection › Maladies virales › Antiviral effects of statins.
questionsmedicales.fr › Virus › Antiviral effects of statins.