Sperm DNA Fragmentation: A New Guideline for Clinicians.
Assisted reproductive techniques outcome
Clinical guidelines
Infertility, male
Oxidative stress
Sperm DNA fragmentation
Journal
The world journal of men's health
ISSN: 2287-4208
Titre abrégé: World J Mens Health
Pays: Korea (South)
ID NLM: 101596899
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
11
07
2020
revised:
13
07
2020
accepted:
13
07
2020
pubmed:
11
8
2020
medline:
11
8
2020
entrez:
11
8
2020
Statut:
ppublish
Résumé
Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases of spermatogenesis, which imparts compaction and protects the genetic content. Testicular (defective maturation and abortive apoptosis) and post-testicular (oxidative stress) mechanisms are implicated in the etiology of sperm DNA fragmentation (SDF), which affects both natural and assisted reproduction. Several clinical and environmental factors are known to negatively impact sperm DNA integrity. An increasing number of reports emphasizes the direct relationship between sperm DNA damage and male infertility. Currently, several assays are available to assess sperm DNA damage, however, routine assessment of SDF in clinical practice is not recommended by professional organizations. This article provides an overview of SDF types, origin and comparative analysis of various SDF assays while primarily focusing on the clinical indications of SDF testing. Importantly, we report four clinical cases where SDF testing had played a significant role in improving fertility outcome. In light of these clinical case reports and recent scientific evidence, this review provides expert recommendations on SDF testing and examines the advantages and drawbacks of the clinical utility of SDF testing using Strength-Weaknesses-Opportunities-Threats (SWOT) analysis.
Identifiants
pubmed: 32777871
pii: 38.e44
doi: 10.5534/wjmh.200128
pmc: PMC7502318
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
412-471Subventions
Organisme : American Center for Reproductive Medicine
ID : Andrology Research Fund #500000105879
Pays : United States of America
Organisme : American Center for Reproductive Medicine
ID : 500000105879
Pays : United States of America
Informations de copyright
Copyright © 2020 Korean Society for Sexual Medicine and Andrology.
Déclaration de conflit d'intérêts
The authors have nothing to disclose.
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