Self-powered portable melt electrospinning for in situ wound dressing.
Electrospinning
Hand-hold e-spinning gun
Nanofibers
Wound dressing
Journal
Journal of nanobiotechnology
ISSN: 1477-3155
Titre abrégé: J Nanobiotechnology
Pays: England
ID NLM: 101152208
Informations de publication
Date de publication:
10 Aug 2020
10 Aug 2020
Historique:
received:
29
01
2020
accepted:
05
08
2020
entrez:
12
8
2020
pubmed:
12
8
2020
medline:
1
5
2021
Statut:
epublish
Résumé
Electrospun (e-spun) nanofibers for wound dressing have attracted wide attention due to its large specific surface area, large porosity and breathability. Compared with solution electrospinning (e-spinning), melt e-spinning is more bio-friendly without toxic solvent participation, which provides the possibility of in situ e-spinning on wounds directly. However, previously reported melt e-spinning devices were usually bulky and cumbersome due to their necessary heating unit, and different components were separated to avoid electrostatic interference. In this article, we report on a self-powered hand-held melt e-spinning gun which can work without any external power supply (outdoors). The problem of electrostatic interference for this integrated device was solved by using a special high heat transfer insulation unit. The apparatus is easy and safe to operate by a single hand due to its small volume (24 × 6 × 13 cm PCL fibrous membrane has good biocompatibility and can be in situ electrospun to wound surface as a wound dressing by the portable melt e-spinning gun. Besides wound dressing, this hand-held melt e-spinning gun may be used in 3D printing and experimental teaching demonstration aids.
Sections du résumé
BACKGROUND
BACKGROUND
Electrospun (e-spun) nanofibers for wound dressing have attracted wide attention due to its large specific surface area, large porosity and breathability. Compared with solution electrospinning (e-spinning), melt e-spinning is more bio-friendly without toxic solvent participation, which provides the possibility of in situ e-spinning on wounds directly. However, previously reported melt e-spinning devices were usually bulky and cumbersome due to their necessary heating unit, and different components were separated to avoid electrostatic interference.
RESULTS
RESULTS
In this article, we report on a self-powered hand-held melt e-spinning gun which can work without any external power supply (outdoors). The problem of electrostatic interference for this integrated device was solved by using a special high heat transfer insulation unit. The apparatus is easy and safe to operate by a single hand due to its small volume (24 × 6 × 13 cm
CONCLUSIONS
CONCLUSIONS
PCL fibrous membrane has good biocompatibility and can be in situ electrospun to wound surface as a wound dressing by the portable melt e-spinning gun. Besides wound dressing, this hand-held melt e-spinning gun may be used in 3D printing and experimental teaching demonstration aids.
Identifiants
pubmed: 32778125
doi: 10.1186/s12951-020-00671-w
pii: 10.1186/s12951-020-00671-w
pmc: PMC7416801
doi:
Substances chimiques
Polyesters
0
polycaprolactone
24980-41-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
111Subventions
Organisme : National Natural Science Foundation of China
ID : 51973100
Organisme : National Natural Science Foundation of China
ID : 51673103
Organisme : National Natural Science Foundation of China
ID : 11904193
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