Postprandial effects of a meal low in sulfur amino acids and high in polyunsaturated fatty acids compared to a meal high in sulfur amino acids and saturated fatty acids on stearoyl CoA-desaturase indices and plasma sulfur amino acids: a pilot study.
Cysteine
Methionine restriction
Stearoyl CoA-desaturase
Sulfur amino acid restriction
Vegan
Vegetarian
Journal
BMC research notes
ISSN: 1756-0500
Titre abrégé: BMC Res Notes
Pays: England
ID NLM: 101462768
Informations de publication
Date de publication:
10 Aug 2020
10 Aug 2020
Historique:
received:
18
03
2020
accepted:
04
08
2020
entrez:
12
8
2020
pubmed:
12
8
2020
medline:
15
5
2021
Statut:
epublish
Résumé
The sulfur amino acid (SAA) cysteine is positively related, whereas polyunsaturated fatty acids (PUFAs) are inversely related to activity of the lipogenic enzyme stearoyl-CoA desaturase (SCD). High SCD activity promotes obesity in animals, and plasma activity indices positively associates with fat mass in humans. SCD may thus be a target for dietary intervention with SAA restriction and PUFA enrichment with unknown potential benefits for body composition. We randomized ten healthy individuals to a meal restricted in SAAs and enriched with PUFAs (Cys/Met SCD16 was unchanged whereas SCD18 tended to increase in the Cys/Met
Identifiants
pubmed: 32778150
doi: 10.1186/s13104-020-05222-y
pii: 10.1186/s13104-020-05222-y
pmc: PMC7419218
doi:
Substances chimiques
Amino Acids, Sulfur
0
Fatty Acids
0
Fatty Acids, Unsaturated
0
Stearoyl-CoA Desaturase
EC 1.14.19.1
Coenzyme A
SAA04E81UX
Banques de données
ClinicalTrials.gov
['NCT02647970']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
379Subventions
Organisme : Norges Forskningsråd
ID : 239948
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