Prevalence and quantitative assessment of macrophages in coronary plaques.

Aged Biomarkers / blood C-Reactive Protein / analysis Cholesterol, LDL / blood Coronary Artery Disease / blood Coronary Vessels / diagnostic imaging Databases, Factual Female Humans Macrophages / pathology Male Middle Aged Plaque, Atherosclerotic Predictive Value of Tests Prognosis Registries Tomography, Optical Coherence

Coronary plaques Macrophages Optical coherence tomography

Journal

The international journal of cardiovascular imaging

ISSN: 1875-8312

Titre abrégé: Int J Cardiovasc Imaging

Pays: United States

ID NLM: 100969716

Informations de publication

Date de publication:
Jan 2021

Historique:

received: 17 03 2020

accepted: 24 07 2020

pubmed: 12 8 2020

medline: 13 4 2021

entrez: 12 8 2020

Statut: ppublish

Résumé

Although optical coherence tomography (OCT) proved to be able to identify macrophage clusters, there are no available data on the possibility to obtain reproducible measurements of their circumferential extension and location. The purpose of the present post-hoc analysis of the CLIMA study was to revise the clinical and demographic variables of patients having coronary plaques with macrophages and to investigate the reproducibility of their quantitative assessment. A total of 577 patients out of 1003 undergoing OCT showed macrophage accumulation. Three groups were identified; group 1 (426 patients) without macrophages, group 2 (296) patients with low macrophage content (less than median value [67°] of circumferential arc) and group 3 (281) with high macrophage content arc [> 67°]. Patients with macrophages (groups 2 and 3) showed a higher prevalence of family history for coronary artery disease and hypercholesterolemia and had a significantly larger body mass index. Furthermore, group 3 had more commonly triple vessel disease and higher value of LDL cholesterol levels compared to the two other groups. The inter-observer agreement for macrophage interpretation was good: R values were 0.97 for the circumferential arc extension, 0.95 for the minimum distance and 0.98 for the mean distance. A non-significant correlation between circumferential extension of macrophages and hsCRP values was found (R = 0.013). Quantitative assessment of macrophage accumulations can be obtained with high reproducibility by OCT. The presence and amount of macrophages are poorly correlated with hsCRP and identify patients with more advanced atherosclerosis and higher LDL cholesterol levels.

Identifiants

DOI: 10.1007/s10554-020-01957-8 PMID: 32779079

pubmed: 32779079

doi: 10.1007/s10554-020-01957-8

pii: 10.1007/s10554-020-01957-8

doi:

Substances chimiques

Biomarkers 0

Cholesterol, LDL 0

C-Reactive Protein 9007-41-4

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Pagination

37-45

Références

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