The Changes of Heart miR-1 and miR-133 Expressions following Physiological Hypertrophy Due to Endurance Training.
Endurance Training
Hand2
Mef2c
miR-1
miR-133
Journal
Cell journal
ISSN: 2228-5806
Titre abrégé: Cell J
Pays: Iran
ID NLM: 101566618
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
16
06
2019
accepted:
12
10
2019
entrez:
12
8
2020
pubmed:
12
8
2020
medline:
12
8
2020
Statut:
ppublish
Résumé
MicroRNAs (miRNAs) play a key role in the development of the heart. Recent studies have shown that miR- 1 and miR-133 are key regulators of cardiac hypertrophy. Therefore, we aimed to evaluate the effect of an endurance training (ET) program on the expressions of these miRNAs and their transcriptional network. In this experimental study, cardiac hypertrophy was induced by 14 weeks of ET for 1 hour per day, 6 days per week at 75% VO2 max). The rats (221 ± 23 g) in the experimental (n=7) and control (n=7) groups were anesthetized to evaluate heart morphology changes by echocardiography. Next, we evaluated expressions of miR-1 and miR-133, and heart and neural crest derivatives express 2 The echocardiography result confirmed physiological hypertrophy in the experimental group that underwent ET as shown by the increased left ventricular weight/body surface area (LVW/BSA) (P=0.004), LVW/body weight (BW) (P=0.011), left ventricular diameter end-diastolic (LVDd) (P=0.003), and improvements in heart functional indexes such as fractional shortness (FS) (P=0.036) and stroke volume (SV) (P=0.002). There were significant increases in the expressions of miR-1 (P=0.001) and miR-133 (P=0.004). The expressions of The expressions of miR-1 and miR-133 and their target genes appeared to be involved in physiological hypertrophy induced by ET in these rats.
Identifiants
pubmed: 32779443
doi: 10.22074/cellj.2020.7014
pmc: PMC7481891
doi:
Types de publication
Journal Article
Langues
eng
Pagination
133-140Informations de copyright
Copyright© by Royan Institute. All rights reserved.
Déclaration de conflit d'intérêts
There is no conflict of interest in this study.
Références
PLoS One. 2013;8(1):e55056
pubmed: 23372811
Lab Anim. 2009 Apr;43(2):127-37
pubmed: 19237453
Neth Heart J. 2008 Apr;16(4):129-33
pubmed: 18427637
Circulation. 2000 Jan 25;101(3):336-44
pubmed: 10645932
J Am Soc Echocardiogr. 2005 Dec;18(12):1440-63
pubmed: 16376782
Front Endocrinol (Lausanne). 2016 Jun 27;7:76
pubmed: 27445979
Am J Physiol Heart Circ Physiol. 2001 Mar;280(3):H1301-10
pubmed: 11179077
J Exerc Rehabil. 2016 Feb 01;12(1):37-41
pubmed: 26933658
J Am Heart Assoc. 2013 Apr 23;2(2):e000078
pubmed: 23612897
Nat Med. 2007 May;13(5):613-8
pubmed: 17468766
J Cachexia Sarcopenia Muscle. 2018 Feb;9(1):20-27
pubmed: 29193905
Nat Genet. 2006 Feb;38(2):228-33
pubmed: 16380711
EMBO J. 2001 Nov 15;20(22):6414-23
pubmed: 11707412
Development. 2001 Nov;128(22):4623-33
pubmed: 11714687
J Card Fail. 2012 Sep;18(9):734-44
pubmed: 22939043
J Am Assoc Lab Anim Sci. 2011 Jul;50(4):454-61
pubmed: 21838971
Circulation. 2005 Nov 8;112(19):2930-9
pubmed: 16260633
Am J Physiol. 1982 Dec;243(6):H941-7
pubmed: 6216817
Nat Rev Cardiol. 2018 Jul;15(7):387-407
pubmed: 29674714
Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20844-9
pubmed: 18093911
Circ Res. 2010 Jan 8;106(1):166-75
pubmed: 19893015
Exp Gerontol. 2018 Aug;109:67-74
pubmed: 28546086
Genes Dev. 2005 Oct 1;19(19):2261-4
pubmed: 16204177
J Am Coll Cardiol. 2002 Oct 16;40(8):1431-6
pubmed: 12392833
J Mol Cell Cardiol. 2008 Jan;44(1):114-22
pubmed: 17980387
Appl Physiol Nutr Metab. 2007 Oct;32(5):852-6
pubmed: 18059609
Cardiology. 2013;125(2):125-30
pubmed: 23711953
Trends Genet. 2008 Apr;24(4):159-66
pubmed: 18325627
Nature. 2005 Jul 14;436(7048):214-20
pubmed: 15951802
Development. 2007 Dec;134(23):4131-40
pubmed: 17959722
Mol Cell Biol. 2008 May;28(10):3437-45
pubmed: 18332106
J Mol Cell Cardiol. 2005 Sep;39(3):479-89
pubmed: 15950986
Biochim Biophys Acta. 2008 Nov;1779(11):682-91
pubmed: 18381085
J Res Med Sci. 2019 Apr 26;24:32
pubmed: 31143233
PLoS One. 2018 Feb 20;13(2):e0193203
pubmed: 29462182