Heritability of specific cognitive functions and associations with schizophrenia spectrum disorders using CANTAB: a nation-wide twin study.

Adult Humans Schizophrenia / genetics Twins, Monozygotic / psychology Twins, Dizygotic / genetics Cognition Neuropsychological Tests
CANTAB cognition heritability psychosis schizophrenia twin

Journal

Psychological medicine
ISSN: 1469-8978
Titre abrégé: Psychol Med
Pays: England
ID NLM: 1254142

Informations de publication

Date de publication:
04 2022
Historique:
pubmed: 12 8 2020
medline: 22 12 2022
entrez: 12 8 2020
Statut: ppublish

Résumé

Many cognitive functions are under strong genetic control and twin studies have demonstrated genetic overlap between some aspects of cognition and schizophrenia. How the genetic relationship between specific cognitive functions and schizophrenia is influenced by IQ is currently unknown. We applied selected tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB) to examine the heritability of specific cognitive functions and associations with schizophrenia liability. Verbal and performance IQ were estimated using The Wechsler Adult Intelligence Scale-III and the Danish Adult Reading Test. In total, 214 twins including monozygotic (MZ = 32) and dizygotic (DZ = 22) pairs concordant or discordant for a schizophrenia spectrum disorder, and healthy control pairs (MZ = 29, DZ = 20) were recruited through the Danish national registers. Additionally, eight twins from affected pairs participated without their sibling. Significant heritability was observed for planning/spatial span ( This study provides further evidence that some cognitive functions are heritable and associated with schizophrenia, suggesting a partially shared genetic etiology. These functions may constitute endophenotypes for the disorder and provide a basis to explore genes common to cognition and schizophrenia.

Sections du résumé

BACKGROUND
Many cognitive functions are under strong genetic control and twin studies have demonstrated genetic overlap between some aspects of cognition and schizophrenia. How the genetic relationship between specific cognitive functions and schizophrenia is influenced by IQ is currently unknown.
METHODS
We applied selected tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB) to examine the heritability of specific cognitive functions and associations with schizophrenia liability. Verbal and performance IQ were estimated using The Wechsler Adult Intelligence Scale-III and the Danish Adult Reading Test. In total, 214 twins including monozygotic (MZ = 32) and dizygotic (DZ = 22) pairs concordant or discordant for a schizophrenia spectrum disorder, and healthy control pairs (MZ = 29, DZ = 20) were recruited through the Danish national registers. Additionally, eight twins from affected pairs participated without their sibling.
RESULTS
Significant heritability was observed for planning/spatial span (
CONCLUSIONS
This study provides further evidence that some cognitive functions are heritable and associated with schizophrenia, suggesting a partially shared genetic etiology. These functions may constitute endophenotypes for the disorder and provide a basis to explore genes common to cognition and schizophrenia.

Identifiants

DOI: 10.1017/S0033291720002858 PMID: 32779562
pubmed: 32779562
doi: 10.1017/S0033291720002858
pii: S0033291720002858
doi:

Types de publication

Twin Study Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1101-1114

Auteurs

Cecilie K Lemvigh (CK)

Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) and Center for Neuropsychiatric Schizophrenia Research, Mental Health Center Glostrup, Glostrup, Denmark.
Department of Psychology, Faculty of Social Sciences, University of Copenhagen, Copenhagen, Denmark.
ORCID: 0000-0002-3647-9709

Rachel M Brouwer (RM)

Department of Psychiatry, UMC Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.

Christos Pantelis (C)

Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) and Center for Neuropsychiatric Schizophrenia Research, Mental Health Center Glostrup, Glostrup, Denmark.
Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Carlton South, Victoria, Australia.

Maria H Jensen (MH)

Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) and Center for Neuropsychiatric Schizophrenia Research, Mental Health Center Glostrup, Glostrup, Denmark.
Child and Adolescent Mental Health Center, Mental Health Services, Capital Region of Denmark.

Rikke W Hilker (RW)

Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) and Center for Neuropsychiatric Schizophrenia Research, Mental Health Center Glostrup, Glostrup, Denmark.
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Christian S Legind (CS)

Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) and Center for Neuropsychiatric Schizophrenia Research, Mental Health Center Glostrup, Glostrup, Denmark.
Mental Health Center North Zealand, Hilleroed, Denmark.

Simon J Anhøj (SJ)

Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) and Center for Neuropsychiatric Schizophrenia Research, Mental Health Center Glostrup, Glostrup, Denmark.
Department of Psychiatry Svendborg, Baagoes Alle 25, 5700 Svendborg, Denmark.

Trevor W Robbins (TW)

Department of Psychology, University of Cambridge, Cambridge, UK.
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.

Barbara J Sahakian (BJ)

Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
Department of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UK.

Birte Y Glenthøj (BY)

Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) and Center for Neuropsychiatric Schizophrenia Research, Mental Health Center Glostrup, Glostrup, Denmark.
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Birgitte Fagerlund (B)

Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) and Center for Neuropsychiatric Schizophrenia Research, Mental Health Center Glostrup, Glostrup, Denmark.
Department of Psychology, Faculty of Social Sciences, University of Copenhagen, Copenhagen, Denmark.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Heritability of specific cognitive functions...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Heritability of specific cognitive functions...
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Schizophrénie › Heritability of specific cognitive functions...
questionsmedicales.fr › Personnes › Progéniture de naissance multiple › Jumeaux › Jumeaux monozygotes › Heritability of specific cognitive functions...
questionsmedicales.fr › Personnes › Progéniture de naissance multiple › Jumeaux › Jumeaux dizygotes › Heritability of specific cognitive functions...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Heritability of specific cognitive functions...
questionsmedicales.fr › Disciplines et activités comportementales › Tests psychologiques › Tests neuropsychologiques › Heritability of specific cognitive functions...