Modeling the metabolic interplay between a parasitic worm and its bacterial endosymbiont allows the identification of novel drug targets.

Animals Brugia malayi / drug effects Drug Evaluation, Preclinical Filariasis / drug therapy Filaricides / pharmacology Metabolic Networks and Pathways / drug effects Models, Biological Symbiosis / drug effects Wolbachia / drug effects
brugia malayi computational biology flux balance analysis infectious disease metabolic reconstruction metabolomics microbiology systems biology wolbachia

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
11 08 2020
Historique:
received: 13 09 2019
accepted: 14 07 2020
entrez: 12 8 2020
pubmed: 12 8 2020
medline: 13 2 2021
Statut: epublish

Résumé

The filarial nematode

Identifiants

DOI: 10.7554/eLife.51850 PMID: 32779567 PMC: PMC7419141
pubmed: 32779567
doi: 10.7554/eLife.51850
pii: 51850
pmc: PMC7419141
doi:
pii:

Substances chimiques

Filaricides 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAID NIH HHS
ID : R21 AI126466
Pays : United States
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : RGPIN-2014-06664
Pays : International
Organisme : NIAID NIH HHS
ID : T32 AI007180
Pays : United States
Organisme : NIAID NIH HHS
ID : F31 AI131527
Pays : United States

Informations de copyright

© 2020, Curran et al.

Déclaration de conflit d'intérêts

DC, AG, NN, AG, DV, DJ, EG, JP No competing interests declared

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Auteurs

David M Curran (DM)

Program in Molecular Medicine, Hospital for Sick Children, Toronto, Canada.
ORCID: 0000-0003-2749-869X

Alexandra Grote (A)

Department of Biology, Center for Genomics and Systems Biology, New York University, New York, United States.

Nirvana Nursimulu (N)

Program in Molecular Medicine, Hospital for Sick Children, Toronto, Canada.
Department of Computer Science, University of Toronto, Toronto, Canada.

Adam Geber (A)

Department of Biology, Center for Genomics and Systems Biology, New York University, New York, United States.
ORCID: 0000-0003-3022-0525

Dennis Voronin (D)

New York Blood Center, New York, United States.

Drew R Jones (DR)

Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, United States.
ORCID: 0000-0001-8732-9818

Elodie Ghedin (E)

Department of Biology, Center for Genomics and Systems Biology, New York University, New York, United States.
Department of Epidemiology, School of Global Public Health, New York University, New York, United States.
ORCID: 0000-0002-1515-725X

John Parkinson (J)

Program in Molecular Medicine, Hospital for Sick Children, Toronto, Canada.
Department of Computer Science, University of Toronto, Toronto, Canada.
Department of Biochemistry, University of Toronto, Toronto, Canada.
Department of Molecular Genetics, University of Toronto, Toronto, Canada.
ORCID: 0000-0001-9815-1189

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Modeling the metabolic interplay between a...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Helminthes › Nematoda › Chromadorea › Spirurida › Filarioidea › Brugia › Brugia malayi › Modeling the metabolic interplay between a...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Modeling the metabolic interplay between a...
questionsmedicales.fr › Infection › Maladies parasitaires › Helminthiase › Nématodoses › Infections à Secernentea › Infections à Spirurida › Filarioses › Modeling the metabolic interplay between a...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Anthelminthiques › Antihelminthiques antinématodes › Filaricides › Modeling the metabolic interplay between a...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Modeling the metabolic interplay between a...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modeling the metabolic interplay between a...
questionsmedicales.fr › Phénomènes biologiques › Symbiose › Modeling the metabolic interplay between a...
questionsmedicales.fr › Bactéries › Proteobacteria › Alphaproteobacteria › Rickettsiales › Anaplasmataceae › Wolbachia › Modeling the metabolic interplay between a...