A theory of joint attractor dynamics in the hippocampus and the entorhinal cortex accounts for artificial remapping and grid cell field-to-field variability.
attractor networks
computational neuroscience
entorhinal cortex
hippcampus
mouse
neuroscience
rat
spatial memory
theoretical neuroscience
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
11 08 2020
11 08 2020
Historique:
received:
13
03
2020
accepted:
07
08
2020
pubmed:
12
8
2020
medline:
26
2
2021
entrez:
12
8
2020
Statut:
epublish
Résumé
The representation of position in the mammalian brain is distributed across multiple neural populations. Grid cell modules in the medial entorhinal cortex (MEC) express activity patterns that span a low-dimensional manifold which remains stable across different environments. In contrast, the activity patterns of hippocampal place cells span distinct low-dimensional manifolds in different environments. It is unknown how these multiple representations of position are coordinated. Here, we develop a theory of joint attractor dynamics in the hippocampus and the MEC. We show that the system exhibits a coordinated, joint representation of position across multiple environments, consistent with global remapping in place cells and grid cells. In addition, our model accounts for recent experimental observations that lack a mechanistic explanation: variability in the firing rate of single grid cells across firing fields, and artificial remapping of place cells under depolarization, but not under hyperpolarization, of layer II stellate cells of the MEC.
Identifiants
pubmed: 32779570
doi: 10.7554/eLife.56894
pii: 56894
pmc: PMC7447444
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : German-Israeli Foundation for Scientific Research and Development
ID : I-1477-421.13/2018
Pays : International
Organisme : Israel Science Foundation
ID : 1745/18
Pays : International
Organisme : Israel Science Foundation
ID : 1978/13
Pays : International
Informations de copyright
© 2020, Agmon and Burak.
Déclaration de conflit d'intérêts
HA, YB No competing interests declared
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