The microbial coinfection in COVID-19.
Anti-Bacterial Agents
/ therapeutic use
Antiviral Agents
/ therapeutic use
Bacterial Infections
/ drug therapy
Betacoronavirus
/ drug effects
COVID-19
Coinfection
Coronavirus Infections
/ drug therapy
Cytokine Release Syndrome
/ drug therapy
Cytokines
/ biosynthesis
Disease Progression
Host-Pathogen Interactions
/ immunology
Humans
Immunity, Innate
/ drug effects
Lymphocytes
/ microbiology
Lymphopenia
/ drug therapy
Mycoses
/ drug therapy
Pandemics
Pneumonia, Viral
/ drug therapy
SARS-CoV-2
Virus Diseases
/ drug therapy
COVID-19
Coinfection
Microorganism
SARS-CoV-2
Journal
Applied microbiology and biotechnology
ISSN: 1432-0614
Titre abrégé: Appl Microbiol Biotechnol
Pays: Germany
ID NLM: 8406612
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
04
06
2020
accepted:
02
08
2020
revised:
07
07
2020
pubmed:
12
8
2020
medline:
2
9
2020
entrez:
12
8
2020
Statut:
ppublish
Résumé
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel β-coronavirus, is the main pathogenic agent of the rapidly spreading pneumonia called coronavirus disease 2019 (COVID-19). SARS-CoV-2 infects much more people, especially the elder population, around the world than other coronavirus, such as SARS-CoV and MERS-CoV, which is challenging current global public health system. Beyond the pathogenesis of SARS-CoV-2, microbial coinfection plays an important role in the occurrence and development of SARS-CoV-2 infection by raising the difficulties of diagnosis, treatment, prognosis of COVID-19, and even increasing the disease symptom and mortality. We summarize the coinfection of virus, bacteria and fungi with SARS-CoV-2, their effects on COVID-19, the reasons of coinfection, and the diagnosis to emphasize the importance of microbial coinfection in COVID-19. KEY POINTS: • Microbial coinfection is a nonnegligible factor in COVID-19. • Microbial coinfection exacerbates the processes of the occurrence, development and prognosis of COVID-19, and the difficulties of clinical diagnosis and treatment. • Different virus, bacteria, and fungi contributed to the coinfection with SARS-CoV-2.
Identifiants
pubmed: 32780290
doi: 10.1007/s00253-020-10814-6
pii: 10.1007/s00253-020-10814-6
pmc: PMC7417782
doi:
Substances chimiques
Anti-Bacterial Agents
0
Antiviral Agents
0
Cytokines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
7777-7785Subventions
Organisme : Sichuan University
ID : 2020scunCoV-10008
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