Improving the Environmental Risk Assessment of Substances of Unknown or Variable Composition, Complex Reaction Products, or Biological Materials.
Complex substances
Ecological risk assessment
Mixtures
Risk assessment
UVCB
Journal
Environmental toxicology and chemistry
ISSN: 1552-8618
Titre abrégé: Environ Toxicol Chem
Pays: United States
ID NLM: 8308958
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
09
04
2020
revised:
11
05
2020
accepted:
03
08
2020
pubmed:
12
8
2020
medline:
7
2
2021
entrez:
12
8
2020
Statut:
ppublish
Résumé
Substances of unknown or variable composition, complex reaction products, or biological materials (UVCBs) pose unique risk assessment challenges to regulators and to product registrants. These substances can contain many constituents, sometimes partially unknown and/or variable, depending on fluctuations in their source material and/or manufacturing process. International regulatory agencies have highlighted the difficulties in characterizing UVCBs and assessing their toxicity and environmental fate. Several industrial sectors have attempted to address these issues by developing frameworks and characterization methods. Based on the output of a 2016 workshop, this critical review examines current practices for UVCB risk assessment and reveals a need for a multipronged and transparent approach integrating whole-substance and constituent-based information. In silico tools or empirical measurements can provide information on discrete and/or blocks of UVCB constituents with similar hazard properties. Read-across and/or whole-substance toxicity and fate testing using adapted emerging methods can provide whole-substance information. Continued collaboration of stakeholders representing government, industry, and academia will facilitate the development of practical testing strategies and guidelines for addressing regulatory requirements for UVCBs. Environ Toxicol Chem 2020;39:2097-2108. © 2020 Health and Environmental Sciences Institute. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Identifiants
pubmed: 32780492
doi: 10.1002/etc.4846
pmc: PMC7693076
doi:
Substances chimiques
Environmental Pollutants
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2097-2108Informations de copyright
© 2020 Health and Environmental Sciences Institute. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Références
Environ Sci Technol. 2004 Dec 1;38(23):6225-33
pubmed: 15597875
Environ Sci Technol. 2016 Jun 7;50(11):5424-31
pubmed: 26804122
Environ Toxicol Chem. 2012 Nov;31(11):2498-506
pubmed: 22887448
Environ Sci Technol. 2019 Mar 19;53(6):3087-3094
pubmed: 30801186
Environ Toxicol Chem. 2015 Nov;34(11):2450-62
pubmed: 26053589
Environ Toxicol Chem. 2004 Oct;23(10):2343-55
pubmed: 15511097
Aquat Toxicol. 2010 Jun 1;98(1):15-24
pubmed: 20170970
Environ Sci Technol. 2018 May 1;52(9):5227-5235
pubmed: 29605991
Environ Sci Technol. 2018 Feb 20;52(4):2143-2151
pubmed: 29376649
Chemosphere. 2018 Mar;195:381-389
pubmed: 29274577
Science. 2020 Jan 24;367(6476):388-392
pubmed: 31974244
Environ Sci Technol. 2012 Mar 6;46(5):2564-73
pubmed: 22260322
PLoS One. 2014 May 02;9(5):e96580
pubmed: 24794244
Science. 2007 Jul 13;317(5835):236-9
pubmed: 17626882
Integr Environ Assess Manag. 2014 Jul;10(3):437-48
pubmed: 24687890
Environ Toxicol Chem. 2019 Mar;38(3):682-694
pubmed: 30638278
Environ Sci Technol. 2020 Apr 21;54(8):4974-4983
pubmed: 32142613
Environ Toxicol Chem. 2009 Jun;28(6):1168-77
pubmed: 19152232