Glucan rich nutrition does not increase gut translocation of beta-glucan.
1-3-beta-D-glucan
fungal translocation
healthy controls
liver cirrhosis
microbial translocation
non-AIDS events
plasma
Journal
Mycoses
ISSN: 1439-0507
Titre abrégé: Mycoses
Pays: Germany
ID NLM: 8805008
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
16
06
2020
revised:
01
08
2020
accepted:
07
08
2020
pubmed:
12
8
2020
medline:
20
7
2021
entrez:
12
8
2020
Statut:
ppublish
Résumé
(1-3)-b-D-glucan (BDG) is a fungal cell wall component and, in the absence of invasive fungal infection, a novel biomarker for microbial translocation of endogenous fungal products from the gastrointestinal tract into systemic circulation. However, its value as a marker of fungal translocation is limited by a concern that plant BDG-rich food influences blood BDG levels. We conducted a pilot clinical trial to evaluate the impact of a standardised oral BDG challenge on blood BDG levels in participants with and without elevated microbial translocation. We enrolled 14 participants including 8 with HIV infection, 2 with advanced liver cirrhosis, and 4 healthy controls. After obtaining a baseline blood sample, participants received a standardised milkshake containing high levels of BDG followed by serial blood samples up to 8 hours after intake. The standardised oral BDG challenge approach did not change the blood BDG levels over time in all participants. We found consistently elevated blood BDG levels in one participant with advanced liver cirrhosis and a single person with HIV with a low CD4 count of 201 cells/mm Our findings indicate that BDG blood levels were not influenced by plant origin BDG-rich nutrition in PWH, people with advanced liver cirrhosis, or healthy controls. Future studies are needed to analyse gut mycobiota populations in individuals with elevated blood BDG levels.
Sections du résumé
BACKGROUND
BACKGROUND
(1-3)-b-D-glucan (BDG) is a fungal cell wall component and, in the absence of invasive fungal infection, a novel biomarker for microbial translocation of endogenous fungal products from the gastrointestinal tract into systemic circulation. However, its value as a marker of fungal translocation is limited by a concern that plant BDG-rich food influences blood BDG levels.
METHODS
METHODS
We conducted a pilot clinical trial to evaluate the impact of a standardised oral BDG challenge on blood BDG levels in participants with and without elevated microbial translocation. We enrolled 14 participants including 8 with HIV infection, 2 with advanced liver cirrhosis, and 4 healthy controls. After obtaining a baseline blood sample, participants received a standardised milkshake containing high levels of BDG followed by serial blood samples up to 8 hours after intake.
RESULTS
RESULTS
The standardised oral BDG challenge approach did not change the blood BDG levels over time in all participants. We found consistently elevated blood BDG levels in one participant with advanced liver cirrhosis and a single person with HIV with a low CD4 count of 201 cells/mm
CONCLUSION
CONCLUSIONS
Our findings indicate that BDG blood levels were not influenced by plant origin BDG-rich nutrition in PWH, people with advanced liver cirrhosis, or healthy controls. Future studies are needed to analyse gut mycobiota populations in individuals with elevated blood BDG levels.
Identifiants
pubmed: 32780885
doi: 10.1111/myc.13161
pmc: PMC7736360
mid: NIHMS1651176
doi:
Substances chimiques
Biomarkers
0
Glucans
0
beta-Glucans
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
24-29Subventions
Organisme : NIAID NIH HHS
ID : T32 AI007036
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI147821
Pays : United States
Organisme : NIH HHS
ID : AI036214
Pays : United States
Organisme : NIH HHS
ID : MH113477
Pays : United States
Organisme : CIHR
ID : PTJ 166049
Pays : Canada
Organisme : NIAID NIH HHS
ID : P30 AI036214
Pays : United States
Organisme : CIHR
ID : HOP 103230
Pays : Canada
Organisme : NIAID NIH HHS
ID : P01 AI131385
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH113477
Pays : United States
Organisme : NICHD NIH HHS
ID : R21 HD094646
Pays : United States
Organisme : NIDA NIH HHS
ID : DP2 DA051915
Pays : United States
Informations de copyright
© 2020 Wiley-VCH GmbH.
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