Nephroprotective effect of Curculigo orchiodies in streptozotocin-nicotinamide induced diabetic nephropathy in wistar rats.
Anti-oxidant
Curculigo orchiodies
Diabetic nephropathy
Dyslipidemia
Streptozotocin
Journal
Journal of Ayurveda and integrative medicine
ISSN: 0975-9476
Titre abrégé: J Ayurveda Integr Med
Pays: United States
ID NLM: 101551404
Informations de publication
Date de publication:
Historique:
received:
10
04
2019
revised:
25
10
2019
accepted:
07
05
2020
pubmed:
13
8
2020
medline:
13
8
2020
entrez:
13
8
2020
Statut:
ppublish
Résumé
Chronic hyperglycemia induced oxidative stress and dyslipidemia in diabetic nephropathy may lead to chronic renal damage. Thus, counteracting oxidative stress might represent an interesting approach in alleviating hyperglycemia-induced renal damage. The present experimental work was undertaken to explore nephroprotective efficacy of Curculigo orchiodies in streptozotocin-nicotinamide induced diabetic nephropathy in laboratory animals. Single intraperitoneal introduction of freshly prepared STZ (65 mg/kg) was used for induction of diabetic nephropathy in rats, 15 min after NAD administration (230 mg/kg; i.p.). The evaluation of nephropathy was done by assessment of serum glucose level, insulin level and renal function test (albumin, urea and creatinine). In addition to this, lipid profile as well as oxidative stress (TBARS, superoxide dismutase, catalase and reduced glutathione) was evaluated. Augmented levels of blood glucose, albumin, urea and creatinine confirmed the development of nephropathic symptoms in rats. After 30 days of STZ administration, different doses (150, 300 mg/kg and 600 mg/kg; p.o.) of hydroalcoholic and ethanolic extracts of C. orchiodies were administered to rats for 45 days. Curculigo orchiodes significantly attenuated hyperglycemia induced increase in lipid profile, oxidative stress and normalized the renal functions (albumin, urea and creatinine); attributing to the efficacy of C. orchiodies in diabetic nephropathy. These findings suggest that hydroalcholic and ethanolic extract of Curculigo Orchiodes ameliorated the progression of diabetic nephropathy. The observed nephroprotective effect of C. orchiodes is attributed to its hypoglycemic, antioxidant and anti-hyperlipidemic activity.
Sections du résumé
BACKGROUND
BACKGROUND
Chronic hyperglycemia induced oxidative stress and dyslipidemia in diabetic nephropathy may lead to chronic renal damage. Thus, counteracting oxidative stress might represent an interesting approach in alleviating hyperglycemia-induced renal damage.
OBJECTIVE
OBJECTIVE
The present experimental work was undertaken to explore nephroprotective efficacy of Curculigo orchiodies in streptozotocin-nicotinamide induced diabetic nephropathy in laboratory animals.
MATERIALS AND METHODS
METHODS
Single intraperitoneal introduction of freshly prepared STZ (65 mg/kg) was used for induction of diabetic nephropathy in rats, 15 min after NAD administration (230 mg/kg; i.p.). The evaluation of nephropathy was done by assessment of serum glucose level, insulin level and renal function test (albumin, urea and creatinine). In addition to this, lipid profile as well as oxidative stress (TBARS, superoxide dismutase, catalase and reduced glutathione) was evaluated. Augmented levels of blood glucose, albumin, urea and creatinine confirmed the development of nephropathic symptoms in rats. After 30 days of STZ administration, different doses (150, 300 mg/kg and 600 mg/kg; p.o.) of hydroalcoholic and ethanolic extracts of C. orchiodies were administered to rats for 45 days.
CONCLUSION
CONCLUSIONS
Curculigo orchiodes significantly attenuated hyperglycemia induced increase in lipid profile, oxidative stress and normalized the renal functions (albumin, urea and creatinine); attributing to the efficacy of C. orchiodies in diabetic nephropathy. These findings suggest that hydroalcholic and ethanolic extract of Curculigo Orchiodes ameliorated the progression of diabetic nephropathy. The observed nephroprotective effect of C. orchiodes is attributed to its hypoglycemic, antioxidant and anti-hyperlipidemic activity.
Identifiants
pubmed: 32782114
pii: S0975-9476(19)30292-X
doi: 10.1016/j.jaim.2020.05.006
pmc: PMC7772483
pii:
doi:
Types de publication
Journal Article
Langues
eng
Pagination
399-404Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
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