Efficacy and safety of modified electroconvulsive therapy for the refractory depression in older patients.
modified electroconvulsive therapy
older patients
refractory depression
safety
Journal
Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists
ISSN: 1758-5872
Titre abrégé: Asia Pac Psychiatry
Pays: Australia
ID NLM: 101506757
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
26
12
2019
accepted:
21
07
2020
pubmed:
13
8
2020
medline:
13
8
2021
entrez:
13
8
2020
Statut:
ppublish
Résumé
We explored the clinical efficacy and safety of modified electroconvulsive therapy (ECT) in the treatment of elderly patients with refractory depression. A total of 43 older patients with refractory depression were enrolled in our study from March 2014 to February 2015, with the average age of 65 ± 4.8 years old. Modified electroconvulsive therapy (ECT) was performed in these patients after physical examinations and anesthesia procedures. Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) were used to assessing the efficacy of ECT, and Wechsler Memory Scale (WMS) and mini-mental state examination (MMSE) were used to evaluate the memory ability and cognitive function. The rate of efficacy was calculated as 67.44% after 4 weeks of ECT treatment. Our results showed that HAMA and HAMD scores after 2 weeks of ECT treatment were significantly lower than pretreatment, and the differences were more significant after 4 weeks of ECT treatment. Compared with pretreatment, the scores of memory quotient and immediate memory of WMS decreased significantly after 1 week of treatment. However, these events were not be presented with the progress of treatment, except for after 2 weeks of treatment. Our results demonstrated that compared with pretreatment, the scores of MMSE significantly increased after 4 weeks of treatment. ECT is an effective, well-tolerated, and safe method for the treatment of older patients with refractory depression. ECT can be recommended for the treatment of these patients after conducting effective risk control of comorbid somatic diseases.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12411Informations de copyright
© 2020 John Wiley & Sons Australia, Ltd.
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